Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Diarylprolinol silyl ethers are among the most utilized stereoselective organocatalysts for the
construction of complex molecules. With their debut in 2005, these catalysts have been …

The ongoing metabolic and microbicidal pathways that support and protect cellular life
generate potentially damaging reactive oxygen species (ROS). To counteract damage, cells …

Cell membranes contain hundreds of different proteins and lipids in an asymmetric
arrangement. Our current understanding of the detailed organization of cell membranes …

We extended thermal proteome profiling to detect transmembrane protein–small molecule
interactions in cultured human cells. When we assessed the effects of detergents on ATP …

Abstract Na+, K+-ATPase pumps three Na+ ions out of cells in exchange for two K+ taken up
from the extracellular medium per ATP molecule hydrolysed, thereby establishing Na+ and …

Abstract Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active
transport of phospholipids from exoplasmic or luminal leaflets to cytosolic leaflets of …

Identifying the genetic mechanisms of adaptation requires the elucidation of links between
the evolution of DNA sequence, phenotype, and fitness. Convergent evolution can be used …

Cardiotonic steroids (CTSs) are specific and potent inhibitors of the Na+, K+-ATPase, with
highest affinity to the phosphoenzyme (E2P) forms. CTSs are comprised of a steroid core …

We describe the development and characterization of a mouse and human epithelial cell
monolayer platform of the small and large intestines, with a broad range of potential …