Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis

SU Khan, AN Lone, MS Khan, SS Virani… - …, 2021 - thelancet.com
Background The effects of omega-3 fatty acids (FAs), such as eicosapentaenoic (EPA) and
docosahexaenoic (DHA) acids, on cardiovascular outcomes are uncertain. We aimed to …

Emerging mechanisms of cardiovascular protection for the omega-3 fatty acid eicosapentaenoic acid

RP Mason, P Libby, DL Bhatt - Arteriosclerosis, thrombosis, and …, 2020 - Am Heart Assoc
Patients with well-controlled LDL (low-density lipoprotein) levels still have residual
cardiovascular risk associated with elevated triglycerides. Epidemiological studies have …

Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia

DL Bhatt, PG Steg, M Miller, EA Brinton… - … England Journal of …, 2019 - Mass Medical Soc
Background Patients with elevated triglyceride levels are at increased risk for ischemic
events. Icosapent ethyl, a highly purified eicosapentaenoic acid ethyl ester, lowers …

Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial

MJ Budoff, DL Bhatt, A Kinninger… - European Heart …, 2020 - academic.oup.com
Aims Despite the effects of statins in reducing cardiovascular events and slowing
progression of coronary atherosclerosis, significant cardiovascular (CV) risk remains …

Coronary Atherosclerotic Plaque Regression: JACC State-of-the-Art Review

LP Dawson, M Lum, N Nerleker, SJ Nicholls… - Journal of the American …, 2022 - jacc.org
Over the last 3 decades there have been substantial improvements in treatments aimed at
reducing cardiovascular (CV) events. As these treatments have been developed, there have …

Effects of icosapent ethyl on total ischemic events: from REDUCE-IT

DL Bhatt, PG Steg, M Miller, EA Brinton… - Journal of the American …, 2019 - jacc.org
Background: In time-to-first-event analyses, icosapent ethyl significantly reduced the risk of
ischemic events, including cardiovascular death, among patients with elevated triglycerides …

Role of omega-3 fatty acids in cardiovascular disease: the debate continues

SCR Sherratt, P Libby, MJ Budoff, DL Bhatt… - Current atherosclerosis …, 2023 - Springer
Abstract Purpose of Review The omega-3 fatty acids (n3-FAs), eicosapentaenoic acid (EPA)
and docosahexaenoic acid (DHA), have recently undergone testing for their ability to reduce …

Coronary heart disease risk: low-density lipoprotein and beyond

GE Shaya, TM Leucker, SR Jones, SS Martin… - Trends in cardiovascular …, 2022 - Elsevier
Coronary heart disease (CHD) is the leading cause of morbidity and mortality world-wide
and has been characterized as a chronic immunoinflammatory, fibroproliferative disease …

New insights into mechanisms of action for omega-3 fatty acids in atherothrombotic cardiovascular disease

R Preston Mason - Current atherosclerosis reports, 2019 - Springer
Abstract Purpose of Review Treatment of hypercholesterolemia with statins results in
significant reductions in cardiovascular risk; however, individuals with well-controlled low …

The eicosapentaenoic acid: arachidonic acid ratio and its clinical utility in cardiovascular disease

JR Nelson, S Raskin - Postgraduate medicine, 2019 - Taylor & Francis
Eicosapentaenoic acid (EPA) is a key anti-inflammatory/anti-aggregatory long-chain
polyunsaturated omega-3 fatty acid. Conversely, the omega-6 fatty acid, arachidonic acid …