Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global
morbidity, disability, and mortality, highlighting the necessity for transformative treatment …

Podophyllotoxin is a naturally occurring cyclolignan isolated from rhizomes of Podophyllum
sp. In the clinic, it is used mainly as an antiviral; however, its antitumor activity is even more …

Natural products (NPs) have consistently played a pivotal role in pharmaceutical research,
exerting profound impacts on the treatment of human diseases. A significant proportion of …

E-selectin, which is highly expressed in vascular endothelial cells near tumor and get
involved in the all tumor growth steps: occurrence, proliferation and metastasis, is …

Postbiotics are preparations of inanimate microorganisms and/or their components that are
beneficial to host health. Compared with probiotics, the postbiotic dose required for exerting …

Podophyllotoxin is an aryltetralin lignan lactone derived from different plants of
Podophyllum. It consists of five rings with four chiral centers, one trans‐lactone and one aryl …

Highlights•We described a detailed account of all the advances on podophyllotoxin
derivatives targeting tubulin from 2017 and 2022.•This review comprehensively summarized …

Podophyllotoxin (PPT) is used in the industrial production of efficient anticancer, antiviral
and other drugs. Sinopodophyllum hexandrum or Podophyllum peltatum are natural sources …

Small-molecule prodrug nanoassembly technology with a unique advantage in off-target
toxicity reduction has been widely used for antitumor drug delivery. However, prodrug …

Podophyllotoxin (PPT) is an active pharmaceutical ingredient (API) with established
antitumor potential. However, due to its systemic toxicity, its use is restricted to topical …