Despite progress in the development of anti-seizure drugs, drug-resistant epilepsy (DRE)
occurs in a third of patients. DRE is associated with poor quality of life and increased risk of …

Pharmacogenomic studies in epilepsy are justified by the high prevalence rate of this
disease and the high cost of its treatment, frequent drug resistance, different response to the …

Simple and fast methods for the detection of target genes with single-nucleotide specificity
could open up genetic research and diagnostics beyond laboratory settings. We recently …

Drug-resistant epilepsy (DRE) affects approximately one third of epileptic patients. Among
various theories that try to explain multidrug resistance, the transporter hypothesis is the …

Abstract Cerebral Cavernous Malformation (CCM) is a cerebrovascular disease of genetic
origin affecting 0.5% of the population and characterized by abnormally enlarged and leaky …

CRISPR/Cas systems have been widely employed for nucleic acid biosensing and have
been further advanced for mutation detection by virtue of the sequence specificity of crRNA …

Drug resistance continues to be a major clinical problem in the therapeutic management of
canine epilepsies with substantial implications for quality of life and survival times …

Epilepsy is a common, serious neurological disorder worldwide. Although this disease can
be successfully treated in most cases, not all patients respond favorably to medical …

Drug-resistant epilepsy affects approximately one-third of the patients with epilepsy. The
pharmacoresistant condition in epilepsy is mainly explained by six hypotheses. In addition …

Epilepsy refers to a common chronic neurological disorder that affects all age groups.
Unfortunately, antiepileptic drugs are ineffective in about one-third of patients. The complex …