Skin microbiota: a source of disease or defence?

AL Cogen, V Nizet, RL Gallo - British journal of dermatology, 2008 - academic.oup.com
Microbes found on the skin are usually regarded as pathogens, potential pathogens or
innocuous symbiotic organisms. Advances in microbiology and immunology are revising our …

Directed evolution of enzymes for industrial biocatalysis

JL Porter, RA Rusli, DL Ollis - ChemBioChem, 2016 - Wiley Online Library
Enzymes have the potential to catalyse a wide variety of chemical reactions. They are
increasingly being sought as environmentally friendly and cost‐effective alternatives to …

Proteases as therapeutics

CS Craik, MJ Page, EL Madison - Biochemical Journal, 2011 - portlandpress.com
Proteases are an expanding class of drugs that hold great promise. The US FDA (Food and
Drug Administration) has approved 12 protease therapies, and a number of next generation …

Understanding the immunogenicity and antigenicity of nanomaterials: Past, present and future

AN Ilinskaya, MA Dobrovolskaia - Toxicology and applied pharmacology, 2016 - Elsevier
Nanoparticle immunogenicity and antigenicity have been under investigation for many
years. During the past decade, significant progress has been made in understanding what …

A deep learning based data driven soft sensor for bioprocesses

V Gopakumar, S Tiwari, I Rahman - Biochemical engineering journal, 2018 - Elsevier
Developing accurate and robust sensors for nonlinear and highly varying systems is a
challenge. Deep learning, an advanced technique to learn deep architectures, has become …

The biochemical and physical process of fibrinolysis and effects of clot structure and stability on the lysis rate

JW Weisel, RI Litvinov - Cardiovascular & Hematological …, 2008 - ingentaconnect.com
The effectiveness of fibrinolysis results from the combination of regulated enzymatic activity
and the physical properties of the fibrin scaffold. Physiologically, clots or thrombi are …

Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K/Akt‐eNOS Signaling Pathway in H2O2‐Induced HUVECs

L Liao, L Gong, M Zhou, X Xue, Y Li… - Oxidative medicine and …, 2021 - Wiley Online Library
Thrombus is considered to be the pathological source of morbidity and mortality of
cardiovascular disease and thrombotic complications, while oxidative stress is regarded as …

The evolution of recombinant thrombolytics: Current status and future directions

Adivitiya, YP Khasa - Bioengineered, 2017 - Taylor & Francis
Cardiovascular disorders are on the rise worldwide due to alcohol abuse, obesity,
hypertension, raised blood lipids, diabetes and age-related risks. The use of classical …

A critical review on marine serine protease and its inhibitors: A new wave of drugs?

N Barzkar, Z Khan, ST Jahromi, S Pourmozaffar… - International Journal of …, 2021 - Elsevier
Marine organisms are rich sources of enzymes and their inhibitors having enormous
therapeutic potential. Among different proteolytic enzymes, serine proteases, which can be …

The molecular basis of thrombolysis and its clinical application in stroke

V Murray, B Norrving, PAG Sandercock… - Journal of internal …, 2010 - Wiley Online Library
Murray V, Norrving B, Sandercock PAG, Terént A, Wardlaw JM, Wester P (Karolinska
Institutet Danderyd Hospital, Stockholm; Department of Neurology, Lund, Sweden; Division …