The monovalent methyl group is derived from methane through the removal of a hydrogen
atom, 1 and its etymology is directly related to the discovery of methanol. 2 The first reports …

Publisher Summary Turns are a fundamental class of polypeptide structure and are defined
as sites where the peptide chain reverses its overall direction. In the past 20 years, the …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Delta and mu opioid receptors (DORs and MORs) are inhibitory G protein-coupled receptors
that reportedly cooperatively regulate the transmission of pain messages by substance P …

Peptides, as neurotransmitters, neuromodulators, and hormones, influence a multitude of
physiological processes by signal transduction mediated through receptors. In addition …

The most ubiquitous mode for controlling and modulating cellular function, intercellular
communication, immune response and information-transduction pathways is through …

This review gives a historical perspective, summarizing approximately 25 years of research
on opioids. The “typical” opioid peptides produced in the brain,“atypical” opioids encrypted …

Opiates like morphine and endogenous opioid peptides exert their pharmacological and
physiological effects through binding to their endogenous receptors, opioid receptors. The …

Deltorphins are endogenous linear heptapeptides, isolated from skin extracts of frogs
belonging to the genus Phyllomedusa, that have a higher affinity and selectivity for delta …

Nociceptin (NC), alias Orphanin FQ, has been recently identified as the endogenous ligand
of the opioid receptor‐like 1 receptor (OP4). This new NC/OP4 receptor system belongs to …