Transcription factor EB (TFEB) is considered the master transcriptional regulator of
autophagy and lysosomal biogenesis, which regulates target gene expression through …

Neuronal loss is one of the striking causes of various central nervous system (CNS)
disorders, including major neurodegenerative diseases, such as Alzheimer's disease (AD) …

The C9ORF72-linked diseases amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) are characterized by the nuclear depletion and cytoplasmic accumulation of …

Di-(2-ethylhexyl) phthalate (DEHP), as the most common phthalate, has been extensively
used as a plasticizer to improve the plasticity of agricultural products, which pose severe …

Germ cell formation and embryonic development require ATP synthesized by mitochondria.
The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are …

Mutations in SOD1 cause amyotrophic lateral sclerosis (ALS) through gain-of-function
effects, yet the mechanisms by which misfolded mutant SOD1 (mutSOD1) protein impairs …

A growing body of evidence suggests that the gut microbiota contributes to the development
of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are clinically linked
major neurodegenerative diseases. Notably, TAR DNA-binding protein-43 (TDP43) …

Signaling between the endoplasmic reticulum (ER) and mitochondria regulates many
neuronal functions that are perturbed in amyotrophic lateral sclerosis (ALS) and perturbation …

Alterations in endoplasmic reticulum (ER)-mitochondria associations and in mitochondria-
associated ER membrane (MAM) behavior have been reported in the brain in several …