Purpose Insomnia is problematic for older adults. After behavioral modifications fail to show
adequate response, pharmacologic options are used. The pharmacokinetics of agents used …

Ensuring athletes achieve an appropriate quality and/or quantity of sleep may have
significant implications for performance and recovery and reduce the risk of developing …

Shift work has been associated with a number of health problems including cardiovascular
disease, impaired glucose and lipid metabolism, gastrointestinal discomfort, reproductive …

The present review starts from the classical physiological and nutritional studies related with
food intake control, digestion, transport and absorption of nutrients. It continues with studies …

Background: Analgesics and sedatives are required to maintain a calm and comfortable
mechanically ventilated injured patient. Continuous sedative infusions have been shown to …

Virtually all cells in the body have an intracellular clockwork based on a negative feedback
mechanism. The circadian timekeeping system in mammals is a hierarchical multi-oscillator …

Melatonin is a methoxyindole synthesized within the pineal gland. The hormone is secreted
during the night and appears to play multiple roles within the human organism. The …

Abstract Serotonin [5‐hydroxytryptamine (5‐HT)] and 5‐HT receptors are involved in sleep
and in waking functions such as cognition and mood. Animal and human studies support a …

Background Given the growing worldwide market of non-prescription drugs, monitoring their
misuse in the context of self-medication represents a particular challenge in Public Health …

The prototypic benzodiazepines, such as diazepam, are not only anxiolytic but also produce
sedation. These effects are mediated by GABAA receptors containing either an α1, α2, α3 or …