Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered a
“multisystem” disease that simultaneously suffers from metabolic diseases and hepatic …

Metabolic dysfunction-associated steatohepatitis (MASH) is characterised by cell death of
parenchymal liver cells which interact with their microenvironment to drive disease activity …

Background Recent investigations have proposed a potential causal association between
the occurrence of ferroptosis, nuclear factor kappa B (NF-κB) and ubiquitin-specific protease …

Punicalagin (PUN) was isolated from the peel of pomegranate (Punica granatum L.), is a
polyphenol with anti-inflammatory, hepatoprotective, and antioxidant activities. However, it …

Acute kidney injury (AKI) is a devastating consequence of sepsis, accompanied by high
mortality rates. It was suggested that inflammatory pathways are closely linked to the …

Acute kidney injury (AKI) is often accompanied by uremic encephalopathy resulting from
accumulation of uremic toxins in brain possibly due to impaired blood-brain barrier (BBB) …

Ferroptosis is an emerging type of regulated cell death usually accompanied by the
accumulation of ferrous ions (Fe2+) and lipid peroxides. As the metabolic hub of the body …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcriptional regulator that
plays a protective role against various cardiovascular diseases. Omaveloxolone is a newly …

Methods The effects on interleukin (IL)-6 and-8 secretion and on certain lipid-metabolizing
enzymes of non-cytotoxic concentrations of EPL (0.1 and 0.25 mg/ml) …

Doxorubicin (DOX) is one of the most widely used antineoplastic drugs with known
cardiotoxicity while other organ toxicity, such as hepatotoxicity is not well defined. This study …