Human placenta and trophoblast development: key molecular mechanisms and model systems
M Knöfler, S Haider, L Saleh, J Pollheimer… - Cellular and Molecular …, 2019 - Springer
Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …
[HTML][HTML] Human placental development and function
T Cindrova-Davies, AN Sferruzzi-Perri - Seminars in cell & developmental …, 2022 - Elsevier
The placenta is a transient fetal organ that plays a critical role in the health and wellbeing of
both the fetus and its mother. Functionally, the placenta sustains the growth of the fetus as it …
both the fetus and its mother. Functionally, the placenta sustains the growth of the fetus as it …
The placenta in fetal growth restriction: what is going wrong?
The placenta is essential for the efficient delivery of nutrients and oxygen from mother to
fetus to maintain normal fetal growth. Dysfunctional placental development underpins many …
fetus to maintain normal fetal growth. Dysfunctional placental development underpins many …
A microphysiological model of human trophoblast invasion during implantation
Successful establishment of pregnancy requires adhesion of an embryo to the endometrium
and subsequent invasion into the maternal tissue. Abnormalities in this critical process of …
and subsequent invasion into the maternal tissue. Abnormalities in this critical process of …
Something old, something new: digital quantification of uterine vascular remodelling and trophoblast plugging in historical collections provides new insight into …
STUDY QUESTION What is the physiological extent of vascular remodelling in and
trophoblast plugging of the uterine circulation across the first half of pregnancy? SUMMARY …
trophoblast plugging of the uterine circulation across the first half of pregnancy? SUMMARY …
Early human trophoblast development: from morphology to function
M Gauster, G Moser, S Wernitznig, N Kupper… - Cellular and Molecular …, 2022 - Springer
Human pregnancy depends on the proper development of the embryo prior to implantation
and the implantation of the embryo into the uterine wall. During the pre-implantation phase …
and the implantation of the embryo into the uterine wall. During the pre-implantation phase …
[HTML][HTML] Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology …
Preeclampsia is a syndromic disease of the mother, fetus, and placenta. The main limitation
in early and accurate diagnosis of preeclampsia is rooted in the heterogeneity of this …
in early and accurate diagnosis of preeclampsia is rooted in the heterogeneity of this …
Placental nanoparticle uptake-on-a-chip: the impact of trophoblast syncytialization and shear stress
The placenta is a dynamic and complex organ that plays an essential role in the health and
development of the fetus. Placental disorders can affect the health of both the mother and …
development of the fetus. Placental disorders can affect the health of both the mother and …
Preeclampsia is a syndrome with a cascade of pathophysiologic events
W Gyselaers - Journal of clinical medicine, 2020 - mdpi.com
This review integrates the currently available information on the molecular, cellular, and
systemic mechanisms involved in the pathophysiology of preeclampsia. It highlights that the …
systemic mechanisms involved in the pathophysiology of preeclampsia. It highlights that the …
Estrogen actions in placental vascular morphogenesis and spiral artery remodeling: A comparative view between Humans and Mice
Estrogens, mainly 17β-estradiol (E2), play a critical role in reproductive organogenesis,
ovulation, and fertility via estrogen receptors. E2 is also a well-known regulator of utero …
ovulation, and fertility via estrogen receptors. E2 is also a well-known regulator of utero …