Across mammals, early embryonic development is supported by uterine secretions taken up
through the yolk sac and other foetal membranes (histotrophic nutrition). The marsupial …

Fetal growth restriction associated with hypertensive disorders of pregnancy (FGR‑HDP) is a
prevalent pathology with a higher risk of perinatal morbimortality. In this condition, placental …

During the first trimester of pregnancy, cytotrophoblasts (CTBs) differentiate into extravillous
trophoblasts (EVTs). EVTs migrate from villus to decidua, invade maternal spiral arteries …

Pregnancy disorders include, most commonly, hypertensive disorders, which include
gestational hypertension, preeclampsia, and chronic hypertension with superimposed …

Fetal survival and development is supported by the maternal immune system. Questions
regarding those mechanisms have risen from development of transplantation medicine and …

The transfer of substances via the blood-placenta barrier is tightly regulated and critical for
the fetus and the expecting mother. In case of necessary medical interventions during …

Preeclampsia (PE) is the leading causes of maternal death worldwide as well as a
significant cause of fetal morbidity and mortality, including fetal growth restriction (FGR). The …

The use of color Doppler ultrasound has allowed a better understanding of the
pathophysiological changes of the uterine circulation since early pregnancy. Uterine artery …

In this chapter, two placental circulations are considered. First, the angioarchitecture of the
villous trees is described and discussed in the context of the molecular regulation of …

The placenta is an indispensable organ that connects the mother and fetus, playing various
roles during pregnancy such as material exchange, hormone secretion, immune regulation …