Membranous nephropathy: new pathogenic mechanisms and their clinical implications

E Hoxha, L Reinhard, RAK Stahl - Nature Reviews Nephrology, 2022 - nature.com
Membranous nephropathy (MN) is characterized histomorphologically by the presence of
immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical …

[HTML][HTML] Primary membranous nephropathy

WG Couser - Clinical Journal of the American Society of …, 2017 - journals.lww.com
Membranous nephropathy (MN) is a unique glomerular lesion that is the most common
cause of idiopathic nephrotic syndrome in nondiabetic white adults. About 80% of cases are …

A proposal for a serology-based approach to membranous nephropathy

AS De Vriese, RJ Glassock, KA Nath… - Journal of the …, 2017 - journals.lww.com
Primary membranous nephropathy (MN) is an autoimmune disease mainly caused by
autoantibodies against the recently discovered podocyte antigens: the M-type …

[HTML][HTML] Membranous nephropathy

P Ronco, L Beck, H Debiec, FC Fervenza… - Nature reviews Disease …, 2021 - nature.com
Membranous nephropathy (MN) is a glomerular disease that can occur at all ages. In adults,
it is the most frequent cause of nephrotic syndrome. In~ 80% of patients, there is no …

[HTML][HTML] Membranous nephropathy: integrating basic science into improved clinical management

DC Cattran, PE Brenchley - Kidney international, 2017 - Elsevier
Idiopathic membranous nephropathy (INM) remains a common cause of the nephrotic
syndrome in adults. The autoimmune nature of IMN was clearly delineated in 2009 with the …

[HTML][HTML] The anti-PLA2R antibody in membranous nephropathy: what we know and what remains a decade after its discovery

AE van de Logt, M Fresquet, JF Wetzels, P Brenchley - Kidney international, 2019 - Elsevier
The discovery in 2009 of the M-type phospholipase A2 receptor (PLA2R) as the primary
target in membranous nephropathy (MN) greatly advanced basic and clinical research …

Treatment of membranous nephropathy: time for a paradigm shift

P Ruggenenti, FC Fervenza, G Remuzzi - Nature Reviews Nephrology, 2017 - nature.com
In patients with membranous nephropathy, alkylating agents (cyclophosphamide or
chlorambucil) alone or in combination with steroids achieve remission of nephrotic …

Membranous nephropathy: a journey from bench to bedside

JM Francis, LH Beck Jr, DJ Salant - American Journal of Kidney Diseases, 2016 - Elsevier
Lessons from an animal model that faithfully resembles human membranous nephropathy
(MN) have informed our understanding of the pathogenesis of this organ-specific …

[HTML][HTML] Immunological pathogenesis of membranous nephropathy: focus on PLA2R1 and its role

W Liu, C Gao, H Dai, Y Zheng, Z Dong, Y Gao… - Frontiers in …, 2019 - frontiersin.org
Membranous nephropathy (MN) is the major cause of nephrotic syndrome with special
pathological features, caused by the formation of immune complexes in the space between …

High-dose rituximab and early remission in PLA2R1-related membranous nephropathy

B Seitz-Polski, K Dahan, H Debiec… - Clinical Journal of the …, 2019 - journals.lww.com
Results Remissions occurred in 18 (64%) versus eight (30%) from the NICE and GEMRITUX
cohort (P= 0.02) at month 6, respectively, and in 24 (86%) versus 18 (67%) participants (P …