[HTML][HTML] Systems biology of malaria explored with nonhuman primates

MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …

[HTML][HTML] The nutrient games–Plasmodium metabolism during hepatic development

A Lahree, J Mello-Vieira, MM Mota - Trends in parasitology, 2023 - cell.com
Malaria is a febrile illness caused by species of the protozoan parasite Plasmodium and is
characterized by recursive infections of erythrocytes, leading to clinical symptoms and …

VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center in 2023

J Alvarez-Jarreta, B Amos, C Aurrecoechea… - Nucleic acids …, 2024 - academic.oup.com
Abstract The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB,
https://veupathdb. org) is a Bioinformatics Resource Center funded by the National Institutes …

[HTML][HTML] Disentanglement of single-cell data with biolord

Z Piran, N Cohen, Y Hoshen, M Nitzan - Nature Biotechnology, 2024 - nature.com
Biolord is a deep generative method for disentangling single-cell multi-omic data to known
and unknown attributes, including spatial, temporal and disease states, used to reveal the …

[HTML][HTML] Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets

AA Ruberto, SP Maher, A Vantaux… - Frontiers in Cellular …, 2022 - frontiersin.org
The resilience of Plasmodium vivax, the most widely-distributed malaria-causing parasite in
humans, is attributed to its ability to produce dormant liver forms known as hypnozoites …

A spatiotemporal atlas of mouse liver homeostasis and regeneration

J Xu, P Guo, S Hao, S Shangguan, Q Shi, G Volpe… - Nature Genetics, 2024 - nature.com
The mechanism by which mammalian liver cell responses are coordinated during tissue
homeostasis and perturbation is poorly understood, representing a major obstacle in our …

Moving on: How malaria parasites exit the liver

M Scheiner, PC Burda… - Molecular Microbiology, 2024 - Wiley Online Library
An essential step in the life cycle of malaria parasites is their egress from hepatocytes, which
enables the transition from the asymptomatic liver stage to the pathogenic blood stage of …

[HTML][HTML] Liver in infections: a single-cell and spatial transcriptomics perspective

J Zou, J Li, X Zhong, D Tang, X Fan, R Chen - Journal of biomedical …, 2023 - Springer
The liver is an immune organ that plays a vital role in the detection, capture, and clearance
of pathogens and foreign antigens that invade the human body. During acute and chronic …

[HTML][HTML] Novel systems to study vector-pathogen interactions in malaria

M Parres-Mercader, A Pance… - Frontiers in Cellular and …, 2023 - frontiersin.org
Some parasitic diseases, such as malaria, require two hosts to complete their lifecycle: a
human and an insect vector. Although most malaria research has focused on parasite …

Single-cell views of the Plasmodium life cycle

E Real, L Mancio-Silva - Trends in Parasitology, 2022 - cell.com
Malaria-causing Plasmodium parasites undergo multiple phenotypic transitions as they
cycle between diverse niches in the mammalian and mosquito hosts. Recent applications of …