Pseudomonas aeruginosa is a Gram-negative bacterium belonging to the γ-proteobacteria.
Like other members of the Pseudomonas genus, it is known for its metabolic versatility and …

Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-
positive infections and, importantly, multidrug-resistant tuberculosis. Among various …

Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …

In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas
aeruginosa infections has gradually decreased. This pathogen can be observed in several …

Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide
range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing …

Aminoglycoside antibiotics were among the first antibiotics discovered and used clinically.
Although they have never completely fallen out of favor, their importance has waned due to …

Colistin is a polymyxin antibiotic that was discovered in the late 1940s for the treatment of
gram‐negative infections. After several years of clinical use, its popularity diminished …

Bacteria living as biofilm are frequently reported to exhibit inherent tolerance to antimicrobial
compounds, and might therefore contribute to the persistence of infections. Antimicrobial …

Bactericidal antibiotics alter microbial metabolism as part of their lethality and can damage
mitochondria in mammalian cells. In addition, antibiotic susceptibility is sensitive to …