Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous
system (CNS), characterized by demyelination, neuronal injury, and breaching of the blood …

Background Alzheimer's disease (AD) is highly intertwined with sleep disturbances
throughout its whole natural history. Sleep consists of a major compound of the functionality …

Introduction Four less well-studied but promising “emerging” cerebrospinal fluid (CSF)
biomarkers are elevated in late-onset Alzheimer disease (AD): neurogranin, synaptosomal …

Alzheimer's disease (AD) is characterized by amyloid plaques and tau pathology
(neurofibrillary tangles and neuropil threads). Amyloid plaques are primarily composed of …

Importance Evidence is accumulating that repeated mild traumatic brain injury (mTBI)
incidents can lead to persistent, long-term debilitating symptoms and in some cases a …

Alzheimer's disease (AD) is the most common neurodegenerative disease and its diagnosis
has classically been based on clinical symptoms. Recently, a biological rather than a …

Introduction Cerebrospinal fluid (CSF) biomarkers can identify individuals with Alzheimer's
disease (AD) pathology (eg, amyloid plaques, neurofibrillary tangles), but defined analyte …

Biological staging of individuals with Alzheimer's disease (AD) may improve diagnostic and
prognostic workup of dementia in clinical practice and the design of clinical trials. In this …

The complex multifactorial nature of polygenic Alzheimer's disease (AD) presents significant
challenges for drug development. AD pathophysiology is progressing in a non-linear …

Introduction Identifying CSF‐based biomarkers for the β‐amyloidosis that initiates
Alzheimer's disease (AD) could provide inexpensive and dynamic tests to distinguish AD …