Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation

SR Khan, BK Canales… - Nature Reviews …, 2021 - nature.com
Idiopathic calcium oxalate (CaOx) stones often develop attached to Randall's plaque
present on kidney papillary surfaces. Similar to the plaques formed during vascular …

Oxalate homeostasis

T Ermer, L Nazzal, MC Tio, S Waikar… - Nature Reviews …, 2023 - nature.com
Oxalate homeostasis is maintained through a delicate balance between endogenous
sources, exogenous supply and excretion from the body. Novel studies have shed light on …

LncRNA HOXA11‐AS regulates calcium oxalate crystal–induced renal inflammation via miR‐124‐3p/MCP‐1

Y Li, G Yan, J Zhang, W Chen, T Ding… - Journal of Cellular …, 2020 - Wiley Online Library
Long noncoding RNA (lncRNA) has been suggested to play an important role in a variety of
diseases over the past decade. In a previous study, we identified a novel lncRNA, termed …

Probiotic Lactiplantibacillus plantarum N‐1 could prevent ethylene glycol‐induced kidney stones by regulating gut microbiota and enhancing intestinal barrier …

Z Wei, Y Cui, L Tian, Y Liu, Y Yu, X Jin, H Li… - The FASEB …, 2021 - Wiley Online Library
Defective permeability barrier is considered to be an incentive of hyperuricemia, however,
the link between them has not been proven. Here, we evaluated the potential preventive …

[HTML][HTML] Protein network analysis and functional enrichment via computational biotechnology unravel molecular and pathogenic mechanisms of kidney stone disease

P Peerapen, V Thongboonkerd - biomedical journal, 2023 - Elsevier
Mass spectrometry-based proteomics has been extensively applied to current biomedical
research. From such large-scale identification of proteins, several computational tools have …

Inhibitors of calcium oxalate crystallization for the treatment of oxalate nephropathies

A Kletzmayr, SR Mulay, M Motrapu, Z Luo… - Advanced …, 2020 - Wiley Online Library
Calcium oxalate (CaOx) crystal‐induced nephropathies comprise a range of kidney
disorders, for which there are no efficient pharmacological treatments. Although CaOx …

Exosome-mediated crosstalk between epithelial cells amplifies the cell injury cascade in CaOx stone formation

Y Yang, S Hong, Q Wang, S Wang, Y Xun - Journal of Biological …, 2023 - Springer
Abstract Background Calcium oxalate (CaOx) stone disease is found worldwide. To explore
the role of exosomes as a mediator of intercellular crosstalk during CaOx stone formation …

[HTML][HTML] A precision medicine approach uncovers a unique signature of neutrophils in patients with brushite kidney stones

MS Makki, S Winfree, JE Lingeman… - Kidney International …, 2020 - Elsevier
Introduction We have previously found that papillary histopathology differs greatly between
calcium oxalate and brushite stone formers (SF); the latter have much more papillary mineral …

Discovering inhibitor molecules for pathological crystallization of CaOx kidney stones from natural extracts of medical herbs

S Li, EGJ Macaringue, D Zhou, P Shi, W Tang… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Kidney stones is one of the common diseases of the
urinary system. The primary cause of kidney stone formation is the thermodynamic …

β‐Caryophyllene may attenuate hyperoxaluria‐induced kidney dysfunction in rats by regulating stress marker KIM‐1/MCP‐1 and NF‐κB signaling pathway

X Xu, J Yan - Journal of Biochemical And Molecular Toxicology, 2021 - Wiley Online Library
Abstract β‐Caryophyllene (BCP), a bicyclic sesquiterpene, has proved to exhibit antioxidant
and anti‐inflammatory activities. The present study is carried out to investigate BCP impact …