Nerve agents: what they are, how they work, how to counter them

S Costanzi, JH Machado, M Mitchell - ACS chemical neuroscience, 2018 - ACS Publications
Nerve agents are organophosphorus chemical warfare agents that exert their action through
the irreversible inhibition of acetylcholinesterase, with a consequent overstimulation of …

Cholinesterase reactivators and bioscavengers for pre‐and post‐exposure treatments of organophosphorus poisoning

P Masson, F Nachon - Journal of neurochemistry, 2017 - Wiley Online Library
Organophosphorus agents (OP s) irreversibly inhibit acetylcholinesterase (AC hE) causing a
major cholinergic syndrome. The medical counter‐measures of OP poisoning have not …

Toxicology of organophosphorus compounds in view of an increasing terrorist threat

F Worek, T Wille, M Koller, H Thiermann - Archives of toxicology, 2016 - Springer
The implementation of the Chemical Weapon Convention (CWC), prohibiting the
development, production, storage and use of chemical weapons by 192 nations and the ban …

The evolution of phosphotriesterase for decontamination and detoxification of organophosphorus chemical warfare agents

AN Bigley, FM Raushel - Chemico-biological interactions, 2019 - Elsevier
The organophosphorus chemical warfare agents were initially synthesized in the 1930's and
are some of the most toxic compounds ever discovered. The standard means of …

Diagnostics and treatment of nerve agent poisoning—current status and future developments

N Amend, KV Niessen, T Seeger, T Wille… - Annals of the New …, 2020 - Wiley Online Library
Although 193 states have committed to the Chemical Weapons Convention and 98% of the
declared chemical weapons stockpiles have been destroyed so far, nerve agent poisoning …

Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers

M Goldsmith, N Aggarwal, Y Ashani… - Protein Engineering …, 2017 - academic.oup.com
Improving an enzyme's initially low catalytic efficiency with a new target substrate by an
order of magnitude or two may require only a few rounds of mutagenesis and screening or …

Domestication affects the structure, development and stability of biobehavioural profiles

S Kaiser, MB Hennessy, N Sachser - Frontiers in Zoology, 2015 - Springer
Domestication is an evolutionary process during which the biobehavioural profile
(comprising eg social and emotional behaviour, cognitive abilities, as well as hormonal …

Effective remediation and decontamination of organophosphorus compounds using enzymes: From rational design to potential applications

J Chen, Z Guo, Y Xin, Z Gu, L Zhang, X Guo - Science of the Total …, 2023 - Elsevier
Organophosphorus compounds (OPs) have been widely used in agriculture for decades
because of their high insecticidal efficiency, which maintains and increases crop yields …

Engineering organophosphate hydrolase for enhanced biocatalytic performance: a review

L Wang, Y Sun - Biochemical Engineering Journal, 2021 - Elsevier
The attack of nerve agents and the usage of pesticides bring threats on the safety of human
lives and environments. Release of the threats of these compounds, organophosphorus …

Catalytic bioscavengers in nerve agent poisoning: A promising approach?

F Worek, H Thiermann, T Wille - Toxicology letters, 2016 - Elsevier
The repeated use of the nerve agent sarin against civilians in Syria in 2013 emphasizes the
continuing threat by chemical warfare agents. Multiple studies demonstrated a limited …