Highlights•Orally delivered drug products gradually continue to exceed the Rule-of-five on
Molecular Weight and clogP.•New predictive descriptors and tools, advanced chemistry and …

Artificial intelligence is a rapidly expanding area of research, with the disruptive potential to
transform traditional approaches in the pharmaceutical industry, from drug discovery and …

Due to the strong tendency towards poorly soluble drugs in modern development pipelines,
enabling drug formulations such as amorphous solid dispersions, cyclodextrins, co-crystals …

Many new drug entities are poorly water-soluble and thus require solubility-enhancing
formulations to ensure sufficient bioavailability. On the other hand, it is more and more …

There has been recent interest in using hydroxypropyl cellulose (HPC) for supersaturating
drug formulations. This study investigated the potential for molecular HPC interactions with …

In response to the increasing application of machine learning (ML) across many facets of
pharmaceutical development, this pilot study investigated if ML, using artificial neural …

Amorphous solid dispersions (ASD) have been a successful formulation strategy to
overcome the poor aqueous solubility of many novel drugs, but the development of pediatric …

A webinar series that was organised by the Academy of Pharmaceutical Sciences
Biopharmaceutics focus group in 2021 focused on the challenges of developing clinically …

This study explores the research area of drug solubility in lipid excipients, an area
persistently complex despite recent advancements in understanding and predicting …

The poor solubility and permeability of compounds beyond Lipinski's Rule of Five (bRo5)
are major challenges for cell-based permeability assays. Due to their incompatibility with …