Healthy human lungs have traditionally been considered to be a sterile organ. However,
culture-independent molecular techniques have reported that large numbers of microbes …

Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the
radiographic demonstration of airway enlargement is the common feature of a …

Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent
exacerbations in many patients. There have been no previous international guidelines. The …

Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to
failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms …

Rationale: Eradication and suppression of Pseudomonas aeruginosa is a key priority in
national guidelines for bronchiectasis and is a major focus of drug development and clinical …

Rationale: Exacerbations are key events in the natural history of bronchiectasis, but clinical
predictors and outcomes of patients with frequently exacerbating disease are not well …

Rationale: Sputum neutrophil elastase and serum desmosine, which is a linked marker of
endogenous elastin degradation, are possible biomarkers of disease severity and …

Patients with severe asthma represent a minority of the total asthma population, but carry a
majority of the morbidity and healthcare costs. Achieving better asthma control in this group …

Bronchiectasis is a heterogeneous disease. This study aimed at identifying discrete groups
of patients with different clinical and biological characteristics and long-term outcomes. This …

We evaluated the efficacy and safety of ciprofloxacin dry powder for inhalation (DPI) in
patients with non-cystic fibrosis bronchiectasis, two or more exacerbations in the previous …