Background The overlap between asthma and COPD is increasingly recognised. This
review examines the new insights, treatment and remaining knowledge gaps for asthma …

The term phenotype in the field of COPD is defined as “a single or combination of disease
attributes that describe differences between individuals with COPD as they relate to clinically …

Significant heterogeneity of clinical presentation and disease progression exists within
chronic obstructive pulmonary disease (COPD). Although FEV1 inadequately describes this …

Bronchiectasis is a heterogeneous disease. This study aimed at identifying discrete groups
of patients with different clinical and biological characteristics and long-term outcomes. This …

Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …

Chronic obstructive pulmonary disease (COPD) is a complex disease at the clinical, cellular,
and molecular levels. However, its diagnosis, assessment, and therapeutic management are …

Background There is notable heterogeneity in the clinical presentation of patients with
COPD. To characterise this heterogeneity, we sought to identify subgroups of smokers by …

Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that
likely includes clinically relevant subgroups. Objectives: To identify subgroups of COPD in …

COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there
is not yet consensus on how many COPD subtypes there are and how they should be …

Chronic obstructive pulmonary disease (COPD) is a prevalent smoking-related disease for
which no disease-altering therapies currently exist. As dysregulated TGF-β signaling …