Background & Aims As an indispensable component of store-operated Ca 2+ entry, stromal
interaction molecule 1 (STIM1) is known to promote colorectal cancer and T-cell–mediated …

Aim Downregulated in adenoma (DRA, Slc26a3) is a member of the solute carrier family 26
(SLC 26), family of anion transporters, which is mutated in familial chloride‐losing diarrhoea …

Biotin is an essential vitamin and critical cofactor in several metabolic pathways, and its
deficiency has been linked to several disorders including inflammatory bowel disease (IBD) …

Gut inflammation is a cardinal event occurring in various gastrointestinal diseases
regardless of etiology. A potential mechanism of action for antibiotic growth promoters and …

Human mucin-2 (MUC-2) is the first line of innate host defense in preventing pathogen-
induced epithelial injury. Entamoeba histolytica (Eh) colonizes the mucus layer by binding of …

Taken together, these findings demonstrate the critical roles of the MUC2 mucin and its
various O-glycans in the protection against colitis and colorectal cancer. Consistently …

Host NOD-like receptor family pyrin domain-containing 6 (NLRP6) regulates innate immune
responses and gastrointestinal homeostasis. Its protective role in intestinal colitis and …

Background Inorganic nitrate and nitrite have emerged as alternative substrates for nitric
oxide (NO) generation in the gastrointestinal tract, and have shown to be protective against …

Ulcerative colitis (UC) is a chronic intestinal inflammatory disease. Necroptosis plays an
important role in the pathogenesis of UC. Celastrol, a triterpene from the root bark of the …

Colonic mucus is a key biological hydrogel that protects the gut from infection and physical
damage and mediates host–microbe interactions and drug delivery. However, little is known …