Background Ileocolonic luminal pH has been reported to be abnormally low in inflammatory
bowel disease (IBD) patients, and one of the causative factors may be reduced epithelial …

Background Muc2-deficient mice show no signs of ileal pathology but the mechanisms
remained unknown. Methods Wild-type (WT), Muc2+/−, and Muc2−/− mice were killed at 2 …

Simple Summary The gastrointestinal tract (GIT) microbiota refers to the collection of
microorganisms that colonize the GIT. The composition and diversity of the GIT microbiota …

One of the promising approaches in the therapy of ulcerative colitis is administration of
butyrate, an energy source for colonocytes, into the lumen of the colon. This study …

Background Although in most patients with inflammatory bowel diseases, conservative
therapy is successful, a significant proportion of patients still require surgery once in their …

Ulcerative colitis (UC) is an idiopathic, long-term inflammatory disorder of the colon,
characterized by a continuous remitting and relapsing course. The intestinal mucus barrier is …

To date it remains unclear how probiotics affect the immune system. Bacterial envelope
components may play an essential role, as these are the first to establish bacterial-host cell …

Background The mucus gel layer (MGL) lining the colon is integral to exclusion of bacteria
and maintaining intestinal homeostasis in health and disease. Some MGL defects allowing …

Extracellular nucleotides are released as constitutive danger signals by various cell types
and activate nucleotide (P2) receptors such as P2Y 6 receptor. P2Y 6 activation on …

Objectives. Interactions between the host and gut microbial community contribute to the
pathogenesis of Crohn's disease (CD). In this study, we aimed to detect lipopolysaccharide …