This study evaluated the effects of Bifidobacterium longum 51A on the intestinal mucosa and
inflammatory response in experimental colitis. Colitis was induced by administration of 3.5 …

The functional ecology of the gastrointestinal tract impacts host physiology, and its
dysregulation is at the center of various diseases. The immune system, and specifically …

Tumor necrosis factor (TNF) is a powerful activator of the immune system and a well-
validated target for treatment of autoimmune diseases. Injection of TNF induces systemic …

OBJECTIVE: Intestinal permeability impairment is implicated in many gastrointestinal (GI)
diseases. Chronic diarrhea, defined as the presence of diarrhea for more than 3 weeks in …

Inflammatory bowel disease shows increasing prevalence, however its pathomechanism
and treatment is not fully resolved. Prebiotics are non-digestible carbohydrates which might …

Primary cilia (PC) are important signaling hubs, and we here explored their role in colonic
pathology. In the colon, PC are mostly present on fibroblasts, and exposure of mice to either …

MHC molecules are essential for the adaptive immune response, and they are the most
polymorphic genetic loci in vertebrates. Extreme genetic variation at these loci is paradoxical …

Both idiopathic and infectious forms of colitis disrupt normal intestinal epithelial cell (IEC)
proliferation and differentiation, although the mechanisms involved remain unclear …

Introduction: The intestinal barrier controls the absorption of nutrients and water whilst
helping to prevent the entry of toxins and pathogenic micro-organisms from the lumen into …

Alcohol can potentiate disease in a mouse model of dextran sodium sulfate (DSS) colitis;
however, the underlying mechanism remains to be established. In this study, we assessed …