Goblet cells (GCs) are specialized epithelial cells that line multiple mucosal surfaces and
have a well-appreciated role in barrier maintenance through the secretion of mucus …

Mucins—large, highly glycosylated proteins—are important for the luminal protection of the
gastrointestinal tract. Enterocytes have their apical surface covered by transmembrane …

The Hsp90 molecular chaperone and its Cdc37 cochaperone help stabilize and activate
more than half of the human kinome. However, both the mechanism by which these …

Objective The inner mucus layer in mouse colon normally separates bacteria from the
epithelium. Do humans have a similar inner mucus layer and are defects in this mucus layer …

Background & Aims The mucus layer in the human colon protects against commensal
bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal …

Background The intestinal mucus layer plays a key role in the maintenance of host-
microbiota homeostasis. To document the crosstalk between the host and microbiota, we …

We evaluated immunometabolic functions of novel Lactobacillus fermentum strains (KBL374
and KBL375) isolated from feces of healthy Koreans. The levels of inflammatory cytokines …

Background Gastrointestinal mucositis is defined as inflammation and/or ulcers of the
gastrointestinal tract occurring as a complication of chemotherapy and radiation therapy …

The mucus layer coating the gastrointestinal tract is the front line of innate host defense,
largely because of the secretory products of intestinal goblet cells. Goblet cells synthesize …

Gut microbiota play an important part in the pathogenesis of mucosal inflammation, such as
inflammatory bowel disease (IBD). However, owing to the complexity of the gut microbiota …