There is a groundswell of interest in using genetically engineered sensor bacteria to study
gut microbiota pathways, and diagnose or treat associated diseases. Here, we …

I hypothesize here that the ability of probiotics to synthesize neuroactive compounds
provides a unifying microbial endocrinology‐based mechanism to explain the hitherto …

The intestinal mucus is an efficient system for protecting the epithelium from bacteria by
promoting their clearance and separating them from the epithelial cells, thereby inhibiting …

Colon has been shown to have a two-layered mucus system where the inner layer is devoid
of bacteria. However, a complete overview of the mouse gastrointestinal mucus system is …

Low-grade intestinal inflammation and alterations of gut barrier integrity are found in patients
affected by extraintestinal autoimmune diseases such as type 1 diabetes (T1D), but a direct …

Microbiota have been shown to have a great influence on functions of intestinal epithelial
cells (ECs). The role of indole as a quorum-sensing (QS) molecule mediating intercellular …

The gut epithelium is covered by mucus consisting of mucin polymers connected via
disulfide bonds. The mucus layer limits exposure of epithelial cells to toxins and bacteria. A …

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disease of the
gastrointestinal tract. Although the precise etiology of IBD remains incompletely understood …

ABSTRACT A close symbiotic relationship exists between the intestinal microbiota and its
host. A critical component of gut homeostasis is the presence of a mucus layer covering the …

It is believed that mucoadhesive surface properties on particles delivered to the
gastrointestinal (GI) tract improve oral absorption or local targeting of various difficult-to …