The inner mucus layer (IML) is a critical barrier that protects the colonic epithelium from
luminal threats and inflammatory bowel disease. Innate immune signaling is thought to …

Human inflammatory bowel disease and experimental colitis models in mice are associated
with shifts in intestinal microbiota composition, but it is unclear at what taxonomic …

Ulcerative colitis (UC), which is a major form of inflammatory bowel disease (IBD), is a
chronic relapsing disorder of the gastrointestinal tract affecting millions of people worldwide …

Exercise reduces the risk of inflammatory disease by modulating a variety of tissue and cell
types, including those within the gastrointestinal tract. Recent data indicates that exercise …

The mucosal barrier has three major components, the mucus layer, the epithelial glycocalyx
and the surface epithelium itself, whose integrity largely depends on tight junction function …

Aim The aim of this study was to investigate whether two Lactobacillus reuteri strains (rat‐
derived R2 LC and human‐derived ATCC PTA 4659 (4659)) could protect mice against …

Although alterations in gut microbiota composition during acute colitis have been repeatedly
observed, associated functional changes and the recovery from dysbiosis received little …

The intestinal barrier plays an extremely important role in maintaining the immune
homeostasis of the gut and the entire body. It is made up of an intricate system of cells …

Epithelial permeability is often increased in inflammatory bowel diseases. We hypothesized
that perturbed mitochondrial function would cause barrier dysfunction and hence epithelial …

Trefoil factor family peptides (TFF1, TFF2, TFF3) are typically co-secreted together with
mucins. Tff1 represents a gastric tumor suppressor gene in mice. TFFs are also synthesized …