[HTML][HTML] Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture

F Sommer, N Adam, MEV Johansson, L Xia… - PloS one, 2014 - journals.plos.org
A functional mucus layer is a key requirement for gastrointestinal health as it serves as a
barrier against bacterial invasion and subsequent inflammation. Recent findings suggest …

[HTML][HTML] The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium

F Sommer, F Bäckhed - Mucosal immunology, 2015 - Elsevier
The epithelium is a first line of defense against microorganisms in the gut. Reactive oxygen
species (ROS) have an important role in controlling the normal gut microbiota and …

Unveiling colitis: a journey through the dextran sodium sulfate-induced model

C Yang, D Merlin - Inflammatory Bowel Diseases, 2024 - academic.oup.com
Animal models of inflammatory bowel disease (IBD) are valuable tools for investigating the
factors involved in IBD pathogenesis and evaluating new therapeutic options. The dextran …

A sticky end for gastrointestinal helminths; the role of the mucus barrier

C Sharpe, DJ Thornton, RK Grencis - Parasite immunology, 2018 - Wiley Online Library
Gastrointestinal (GI) nematodes are a group of successful multicellular parasites that have
evolved to coexist within the intestinal niche of multiple species. It is estimated that over 10 …

[HTML][HTML] The goblet cell-derived mediator RELM-β drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis

V Morampudi, U Dalwadi, G Bhinder, HP Sham… - Mucosal …, 2016 - Elsevier
Intestinal goblet cells are potentially key players in controlling susceptibility to ulcerative
colitis (UC). Although impaired mucin (Muc2) production by goblet cells increases microbial …

[HTML][HTML] Calcium-activated chloride channel regulator 1 (CLCA1) controls mucus expansion in colon by proteolytic activity

EEL Nyström, GMH Birchenough, S van der Post… - …, 2018 - thelancet.com
Many epithelial surfaces of the body are covered with protective mucus, and disrupted
mucus homeostasis is coupled to diseases such as ulcerative colitis, helminth infection …

Mucus and the goblet cell

MEV Johansson, GC Hansson - Digestive diseases, 2013 - karger.com
The discovery of an inner mucus layer normally impervious to bacteria has changed our way
of understanding the interaction between commensal bacteria and the host epithelial cells …

Fermented Soybean Meal Increases Lactic Acid Bacteria in Gut Microbiota of Atlantic Salmon (Salmo salar)

N Catalán, A Villasante, J Wacyk, C Ramírez… - Probiotics and …, 2018 - Springer
The main goal of the present study was to address the effect of feeding fermented soybean
meal-based diet to Atlantic salmon on gut microbiota. Further, expression of genes of …

[HTML][HTML] Therapeutic potential to modify the mucus barrier in inflammatory bowel disease

J Sun, X Shen, Y Li, Z Guo, W Zhu, L Zuo, J Zhao, L Gu… - Nutrients, 2016 - mdpi.com
Recently, numerous studies have shown that disruption of the mucus barrier plays an
important role in the exacerbation of inflammatory bowel disease, particularly in ulcerative …

Exploring the influence of the gut microbiota and probiotics on health: a symposium report

LV Thomas, T Ockhuizen, K Suzuki - British Journal of Nutrition, 2014 - cambridge.org
The present report describes the presentations delivered at the 7th International Yakult
Symposium,'The Intestinal Microbiota and Probiotics: Exploiting Their Influence on Health' …