Visualizing lung function with positron emission tomography

RS Harris, DP Schuster - Journal of applied physiology, 2007 - journals.physiology.org
Positron emission tomography (PET) provides three-dimensional images of the distributions
of radionuclides that have been inhaled or injected into the lungs. By using radionuclides …

[图书][B] Pharmaceutical inhalation aerosol technology

AJ Hickey - 2003 - taylorfrancis.com
This thoroughly revised and expanded reference provides authoritative discussions on the
physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors …

Computed tomography studies of lung ventilation and perfusion

EA Hoffman, D Chon - Proceedings of the American Thoracic …, 2005 - atsjournals.org
With the emergence of multidetector-row computed tomography (CT) it is now possible to
image both structure and function via use of a single imaging modality. Breath-hold spiral CT …

Topographical distribution of pulmonary perfusion and ventilation, assessed by PET in supine and prone humans

G Musch, JDH Layfield, RS Harris… - Journal of applied …, 2002 - journals.physiology.org
Using positron emission tomography (PET) and intravenously injected 13N2, we assessed
the topographical distribution of pulmonary perfusion (Q˙) and ventilation (V˙) in six healthy …

Ventilation from four-dimensional computed tomography: density versus Jacobian methods

R Castillo, E Castillo, J Martinez… - Physics in Medicine & …, 2010 - iopscience.iop.org
Two calculation methods to produce ventilation images from four-dimensional computed
tomography (4DCT) acquired without added contrast have been reported. We reported a …

Respiratory gating for 3-dimensional PET of the thorax: feasibility and initial results

L Boucher, S Rodrigue, R Lecomte… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Respiratory motion may reduce the sensitivity of 18F-FDG PET for the detection of small
pulmonary nodules close to the base of the lungs. This motion also interferes with attempts …

The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI

YS Tzeng, K Lutchen, M Albert - Journal of applied …, 2009 - journals.physiology.org
In this pilot study, algorithms for quantitatively evaluating the distribution and heterogeneity
of human ventilation imaged with hyperpolarized (HP) 3He MRI were developed for the goal …

Quantification of regional ventilation-perfusion ratios with PET

MFV Melo, D Layfield, RS Harris, K O'neill… - Journal of Nuclear …, 2003 - Soc Nuclear Med
The topographic matching of alveolar ventilation (V̇ A) and perfusion (Q̇) is the main
determinant of gas exchange efficiency of the lung. However, no pulmonary functional …

Quantitative imaging metrics for the assessment of pulmonary pathophysiology: an official American Thoracic Society and Fleischner Society joint workshop report

CCW Hsia, JHT Bates, B Driehuys, SB Fain… - Annals of the …, 2023 - atsjournals.org
Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …

Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma

RS Harris, T Winkler, N Tgavalekos… - American journal of …, 2006 - atsjournals.org
Rationale: Bronchoconstriction in asthma leads to heterogeneous ventilation and the
formation of large and contiguous ventilation defects in the lungs. However, the regional …