Many factors must be considered and discussed with women when initiating a contraceptive
method and the risk of venous thromboembolism (VTE) is one of them. In this review, we …

Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product.
The reactions catalysed include aromatisation, oxidation, reduction, sulfonation …

Objectives To evaluate the effect on endocrine and metabolic parameters of a new
combined oral contraceptive (COC) containing estetrol (E4) and drospirenone (DRSP) …

Objectives To assess the contraceptive efficacy, bleeding pattern and safety of a combined
oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg. Design …

Objective The incidence of heart disease increases with age, but is lower in women than in
men up to 75 years. A protective effect of female sex hormones or, alternatively, acceleration …

Objective The effects of estetrol (E4), a natural fetal estrogen, combined with drospirenone
(DRSP) were evaluated on plasma levels of sex hormone-binding globulin (SHBG) …

Purpose Despite considerable advances in recently developed combined oral
contraceptives (COCs), resulting in lower rates of adverse events while maintaining …

The combined oral contraceptive pill is an effective contraceptive method which can also
offer other benefits. However, other contraceptive options should be discussed. If the pill is …

In women with premature ovarian insufficiency (POI), hormonal therapy (HT) is indicated to
decrease the risk of morbidity and to treat symptoms related to prolonged hypoestrogenism …

Objective To evaluate the bleeding patterns of a new combined oral contraceptive
containing estetrol (E4) 15 mg/drospirenone (DRSP) 3 mg in a 24/4-day regimen. Study …