The role of B cells in atherosclerosis

AP Sage, D Tsiantoulas, CJ Binder… - Nature Reviews Cardiology, 2019 - nature.com
The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …

Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis–novel insights and future directions in diagnosis and therapy

A Hartley, D Haskard, R Khamis - Trends in Cardiovascular Medicine, 2019 - Elsevier
We provide an up-to-date overview of current topics surrounding oxidized low-density
lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at …

Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies

F Porsch, Z Mallat, CJ Binder - Cardiovascular research, 2021 - academic.oup.com
Immune mechanisms are critically involved in the pathogenesis of atherosclerosis and its
clinical manifestations. Associations of specific antibody levels and defined B-cell subsets …

B cells in atherosclerosis: mechanisms and potential clinical applications

T Pattarabanjird, C Li, C McNamara - Basic to Translational Science, 2021 - jacc.org
Because atherosclerotic cardiovascular disease is a leading cause of death worldwide,
understanding inflammatory processes underpinning its pathology is critical. B cells have …

The impact of type 2 immunity and allergic diseases in atherosclerosis

N Fernández‐Gallego, R Castillo‐González… - Allergy, 2022 - Wiley Online Library
Allergic diseases are allergen‐induced immunological disorders characterized by the
development of type 2 immunity and IgE responses. The prevalence of allergic diseases has …

Immunometabolic function of cholesterol in cardiovascular disease and beyond

L Yvan-Charvet, F Bonacina… - Cardiovascular …, 2019 - academic.oup.com
Inflammation represents the driving feature of many diseases, including atherosclerosis,
cancer, autoimmunity and infections. It is now established that metabolic processes shape a …

Anti-oxidized LDL antibodies and coronary artery disease: a systematic review

VJ van den Berg, MM Vroegindewey, I Kardys… - Antioxidants, 2019 - mdpi.com
Antibodies to oxidized LDL (oxLDL) may be associated with improved outcomes in
cardiovascular disease. However, analysis is restricted by heterogenous study design and …

Reduction of myocardial ischaemia–reperfusion injury by inactivating oxidized phospholipids

C Yeang, D Hasanally, X Que, MY Hung… - Cardiovascular …, 2019 - academic.oup.com
Aims Myocardial ischaemia followed by reperfusion (IR) causes an oxidative burst resulting
in cellular dysfunction. Little is known about the impact of oxidative stress on cardiomyocyte …

Immunodominant MHC-II (major histocompatibility complex II) restricted epitopes in human apolipoprotein B

P Roy, J Sidney, CS Lindestam Arlehamn… - Circulation …, 2022 - Am Heart Assoc
Background: CD (cluster of differentiation) 4+ T-cell responses to APOB (apolipoprotein B)
are well characterized in atherosclerotic mice and detectable in humans. CD4+ T cells …

Inflammation in HIV and its impact on atherosclerotic cardiovascular disease

LM Obare, T Temu, SA Mallal, CN Wanjalla - Circulation research, 2024 - Am Heart Assoc
People living with HIV have a 1.5-to 2-fold increased risk of developing cardiovascular
disease. Despite treatment with highly effective antiretroviral therapy, people living with HIV …