New therapeutic options in congestive heart failure: part I

J McMurray, MA Pfeffer - Circulation, 2002 - Am Heart Assoc
CHF is whether revascularization might substantially improve LV systolic function in patients
with significant areas of hibernation. 20 The definition and best means of detecting …

Candesartan

CH Gleiter, C Jägle, U Gresser… - Cardiovascular drug …, 2004 - Wiley Online Library
Candesartan cilexetil is the prodrug of candesartan, an angiotensin II receptor antagonist.
Candesartan binds selectively and non‐competitively to the angiotensin II receptor type 1 …

Angiotensin receptor blockers and risk of myocardial infarction: systematic review

MA McDonald, SH Simpson, JA Ezekowitz, G Gyenes… - bmj, 2005 - bmj.com
Objective To evaluate the effect of angiotensin receptor blockers on the risk of myocardial
infarction in patients at risk for cardiovascular events. Design Systematic review of controlled …

Efficacy and safety of oral candesartan cilexetil in patients with congestive heart failure

A Matsumori… - European Journal of …, 2003 - Wiley Online Library
Background: Candesartan cilexetil is a new angiotensin II receptor blocker with a high
affinity for the angiotensin II‐subtype 1 receptor. Aims: This 6‐month study examined the …

Interleukin-6 and tumor necrosis factor alpha in relation to myocardial infarct size and collagen formation

M Puhakka, J Magga, S Hietakorpi, I Penttilä… - Journal of cardiac …, 2003 - Elsevier
Background: Interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels increase
after acute myocardial infarction (AMI) in humans. Experimental data suggest that these …

Role of valsartan and other angiotensin receptor blocking agents in the management of cardiovascular disease

J Martin, H Krum - Pharmacological research, 2002 - Elsevier
Blockade of the renin–angiotensin system by angiotensin converting enzyme (ACE)
inhibitors reduces mortality and morbidity in patients post-myocardial infarction as well as in …

Cardiovascular outcomes in high-risk patients without heart failure treated with ARBs: a systematic review and meta-analysis

MM Al Khalaf, L Thalib, SAR Doi - American journal of cardiovascular …, 2009 - Springer
Background and objective Angiotensin II type 1 receptor antagonists (ARBs) are widely used
as a substitute for angiotensin-converting enzyme inhibitors (ACEIs) to treat patients without …

Effects of pre-, peri-, and postmyocardial infarction treatment with losartan in rats: effect of dose on survival, ventricular arrhythmias, function, and remodeling

A Pourdjabbar, TG Parker, QT Nguyen… - American Journal …, 2005 - journals.physiology.org
Angiotensin receptor blockers (ARBs) reduce adverse left ventricular (LV) remodeling and
improve LV function and survival when started postmyocardial infarction (MI). ARBs also …

Dual blockade of angiotensin II with enalapril and losartan reduces proteinuria in hypertensive patients with type 2 diabetes

M Igarashi, A Hirata, Y Kadomoto, M Tominaga - Endocrine journal, 2006 - jstage.jst.go.jp
In this study we evaluated the effect of a dual blockade with enalapril and losartan on the
reduction of overt macroproteinuria and its potential mechanism (s) in hypertensive patients …

[PDF][PDF] Late mortality and determinants in patients with heart failure and preserved systolic left ventricular function: the Israel Nationwide Heart Failure Survey

A Shotan, S Gottlieb, S Behar, J Leor, E Grossman… - Isr Med Assoc J, 2007 - ima.org.il
Background: Heart failure with preserved systolic left ventricular function is a major cause of
cardiac disability. Objectives: To examine the prevalence, characteristics and late clinical …