The diagnosis of amyotrophic lateral sclerosis can be challenging due to its heterogeneity in
clinical presentation and overlap with other neurological disorders. Diagnosis early in the …

Objectives The lack of systematic evidence on neuroimaging findings in motor neuron
diseases (MND) hampers the diagnostic utility of magnetic resonance imaging (MRI). Thus …

Objective To evaluate progressive white matter (WM) degeneration in amyotrophic lateral
sclerosis (ALS). Methods Sixty-six patients with ALS and 43 healthy controls were enrolled …

Deep learning has great potential for accurate detection and classification of diseases with
medical imaging data, but the performance is often limited by the number of training datasets …

Purpose In vivo detection of transactivation response element DNA binding protein-43 kDa
(TDP-43) aggregates through positron emission tomography (PET) would impact the ability …

Purpose Neuropathological data suggest that ALS with SOD1 mutations (SOD1-ALS) is a
distinct form of ALS. We evaluated brain metabolic changes characterizing SOD1-ALS as …

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by
progressive muscle wasting, breathing and swallowing difficulties resulting in patient's death …

Amyotrophic lateral sclerosis (ALS) is a devastating disease with evidence of degeneration
involving upper and lower motor neuron compartments of the nervous system. Presently, two …

Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …

Objective: Amyotrophic lateral sclerosis (ALS) is a clinically heterogenous disease, typically
presenting with focal motor weakness that eventually generalizes. Weather there is a …