Alginate microparticles as oral colon drug delivery device: A review

L Agüero, D Zaldivar-Silva, L Peña, ML Dias - Carbohydrate polymers, 2017 - Elsevier
The increase in the research interest on alginate microparticles in pharmaceutical and
biomedical areas confirms its potential use as an effective matrix for drug and cell delivery …

Theranostic nanoparticles with disease-specific administration strategies

P Zhang, Y Li, W Tang, J Zhao, L Jing, KJ McHugh - Nano Today, 2022 - Elsevier
Recent advances in the synthesis of nanomaterials with diagnostic and therapeutic
capabilities have been rapidly reshaping the landscape of precision medicine. Impressive …

Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells

CS Kumar, R Thangam, SA Mary, PR Kannan… - Carbohydrate …, 2020 - Elsevier
The present study is aimed to study and to evaluate the colon cancer targeting efficacy of
chitosan-coated-trans-resveratrol (RSV) and ferulic acid (FER) loaded SLNs (solid lipid …

[HTML][HTML] Plant-derived exosomes as a drug-delivery approach for the treatment of inflammatory bowel disease and colitis-associated cancer

Y Cai, L Zhang, Y Zhang, R Lu - Pharmaceutics, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic recurrent intestinal disease and includes
Crohn's disease (CD) and ulcerative colitis (UC). Due to the complex etiology of colitis, the …

Targeted therapeutic effects of oral inulin-modified double-layered nanoparticles containing chemotherapeutics on orthotopic colon cancer

Y Hou, J Jin, H Duan, C Liu, L Chen, W Huang, Z Gao… - Biomaterials, 2022 - Elsevier
Colon cancer is emerging as one of the most prevalent cancers globally. Oral colonic drug
delivery systems have attracted considerable attention in the treatment of orthotopic colon …

Nanoparticle-mediated drug delivery systems for the treatment of IBD: current perspectives

C Yang, D Merlin - International journal of nanomedicine, 2019 - Taylor & Francis
Inflammatory bowel disease (IBD), which mainly consists of Crohn's disease and ulcerative
colitis, is a chronic and relapsing inflammatory condition of the gastrointestinal tract. The …

Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET …

X Dong, W Yin, X Zhang, S Zhu, X He… - … applied materials & …, 2018 - ACS Publications
Chemotherapy resistance remains a major hurdle for cancer therapy in clinic because of the
poor cellular uptake and insufficient intracellular release of drugs. Herein, an intelligent …

Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals

P Vass, B Démuth, E Hirsch, B Nagy… - Journal of controlled …, 2019 - Elsevier
In chronic intestinal diseases like inflammatory bowel disease, parenteral administration of
biopharmaceuticals is associated with numerous disadvantages including immune …

Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease

AA Date, G Halpert, T Babu, J Ortiz, P Kanvinde… - Biomaterials, 2018 - Elsevier
Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal disorder that
affects more than 1 million individuals in the USA. Local therapy with enema formulations …

Colon-targeted delivery systems for nutraceuticals: A review of current vehicles, evaluation methods and future prospects

K Feng, Y Wei, T Hu, RJ Linhardt, M Zong… - Trends in Food Science & …, 2020 - Elsevier
Background Advances in nutriology have suggested the colon as a superior site for nutrition
absorption. Nutraceuticals, including phytochemicals, probiotics, etc., have received great …