The neurovascular unit and systemic biology in stroke—implications for translation and treatment
Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …
exist beyond recanalization. The development of novel therapies has been repeatedly …
The role of glymphatic system in Alzheimer's and Parkinson's disease pathogenesis
FR Buccellato, M D'Anca, M Serpente, A Arighi… - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia, whilst
Parkinson's disease (PD) is a neurodegenerative movement disorder. These two …
Parkinson's disease (PD) is a neurodegenerative movement disorder. These two …
Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms
While neuropathological examinations in patients who died from COVID-19 revealed
inflammatory changes in cerebral white matter, cerebral MRI frequently fails to detect …
inflammatory changes in cerebral white matter, cerebral MRI frequently fails to detect …
Glymphatic dysfunction induced oxidative stress and neuro-inflammation in major depression disorders
S Gu, Y Li, Y Jiang, JH Huang, F Wang - Antioxidants, 2022 - mdpi.com
Major Depression disorder (MDD) is a potentially life-threatening mental illness, however,
many patients have a poor response to current treatments. Recent studies have suggested …
many patients have a poor response to current treatments. Recent studies have suggested …
[HTML][HTML] The complex role of inflammation and gliotransmitters in Parkinson's disease
Our understanding of the role of innate and adaptive immune cell function in brain health
and how it goes awry during aging and neurodegenerative diseases is still in its infancy …
and how it goes awry during aging and neurodegenerative diseases is still in its infancy …
DAT and TH expression marks human Parkinson's disease in peripheral immune cells
Parkinson's disease (PD) is marked by a loss of dopamine neurons, decreased dopamine
transporter (DAT) and tyrosine hydroxylase (TH) expression. However, this validation …
transporter (DAT) and tyrosine hydroxylase (TH) expression. However, this validation …
[HTML][HTML] Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and …
Background: Stroke stimulates reactive astrogliosis, aquaporin 4 (AQP4) depolarization and
neuroinflammation. Preconditioned extracellular vesicles (EVs) from microglia exposed to …
neuroinflammation. Preconditioned extracellular vesicles (EVs) from microglia exposed to …
The glymphatic system: a new perspective on brain diseases
Z Ding, X Fan, Y Zhang, M Yao, G Wang… - Frontiers in Aging …, 2023 - frontiersin.org
The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …
Glymphatic dysfunction correlates with severity of small vessel disease and cognitive impairment in cerebral amyloid angiopathy
Background and purpose Cerebral amyloid angiopathy (CAA) is characterized by β‐amyloid
deposition in cortical and leptomeningeal arterioles, which might result from glymphatic …
deposition in cortical and leptomeningeal arterioles, which might result from glymphatic …
Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …
bidirectional transport of water across biological membranes in response to osmotic …