Within a few years after the first successful clinical use of penicillin, investigations were
conducted in animal infection models to explore a range of factors that were considered …

The rapid evolution of antibiotic resistance and the complicated bacterial infection
microenvironments are serious obstacles to traditional antibiotic therapy. Developing novel …

Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …

Background Traditionally, there has been a common belief that ongoing iv antibiotic therapy
is superior to an early iv to oral switch, especially for severe infections. However, this may be …

Bacterial resistance to antibiotics continues to be a global public health problem. The choice
of the most effective antibiotic and the use of an adapted dose in the initial phase of the …

Despite their limitations, the pharmacokinetics (PK) and pharmacodynamics (PD) indices
form the basis for our current understanding regarding antibiotic development, selection …

Vancomycin is a hydrophilic antibiotic widely used in severe infections, including bacteremia
and central nervous system (CNS) infections caused by Gram-positive bacteria such as …

Sepsis is one of the major causes of death in the hospital worldwide. The pathology of
sepsis is tightly associated with dysregulation of innate immune responses. The contribution …

In the present study, population pharmacokinetic (PK) analysis was performed based on
meropenem data from a prospective study conducted in 114 critically ill patients with a wide …

Bacteremia and associated bacterial sepsis are potentially fatal and occur when the host
response to microbial invasion is impaired or compromised. This motivated us to develop …