Following the identification in a proband of a germline BRCA1/BRCA2 mutation in hereditary
breast-ovarian cancer (HBOC) or a DNA mismatch repair gene mutation in Lynch syndrome …

Simple Summary In general, 5–20% of all cancers are due to pathogenic variants in cancer
genes that are passed down in the family. It is recommended that blood relatives of …

The dominant, individualistic understanding of autonomy that features in clinical practice
and research is underpinned by the idea that people are, in their ideal form, independent …

Background This paper proposes a refocusing of consent for clinical genetic testing, moving
away from an emphasis on autonomy and information provision, towards an emphasis on …

European genetic testing guidelines recommend that healthcare professionals (HCPs)
discuss the familial implications of any test with a patient and offer written material to help …

Low uptake of genetic services among members of families with hereditary breast and
ovarian cancer (HBOC) suggests limitations of proband-mediated communication of genetic …

Interventions to assist family communication about inherited cancer risk have the potential to
improve family cancer outcomes. This review aimed to evaluate the efficacy of proband …

Genetic information is a family affair. With the expansion of genomic technologies, many
new causal genes and variants have been established and the potential for molecular …

How 'the patient'is imagined has implications for ethical decision-making in clinical practice.
Patients are predominantly conceived in an individualised manner as autonomous and …

Health benefits to relatives of people at known genetic risk for hereditary cancer syndromes
is key to realizing the promise of precision medicine. We conducted a qualitative study to …