Organoids: The current status and biomedical applications

S Yang, H Hu, H Kung, R Zou, Y Dai, Y Hu… - MedComm, 2023 - Wiley Online Library
Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Advances and challenges toward developing kidney organoids for clinical applications

R Nishinakamura - Cell Stem Cell, 2023 - cell.com
Kidney organoids have enabled modeling of human development and disease. While
methods of generating the nephron lineage are well established, new protocols to induce …

Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids

JM Vanslambrouck, SB Wilson, KS Tan… - Nature …, 2022 - nature.com
While pluripotent stem cell-derived kidney organoids are now being used to model renal
disease, the proximal nephron remains immature with limited evidence for key functional …

A single-cell multiomic analysis of kidney organoid differentiation

Y Yoshimura, Y Muto, N Ledru, H Wu… - Proceedings of the …, 2023 - National Acad Sciences
Kidney organoids differentiated from pluripotent stem cells are powerful models of kidney
development and disease but are characterized by cell immaturity and off-target cell fates …

The “3Ds” of growing kidney organoids: Advances in nephron development, disease modeling, and drug screening

BE Chambers, NE Weaver, RA Wingert - Cells, 2023 - mdpi.com
A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …

Kidney organoids: a pioneering model for kidney diseases

M Tekguc, RC Van Gaal, SGM Uzel, N Gupta… - Translational …, 2022 - Elsevier
The kidney is a vital organ that regulates the bodily fluid and electrolyte homeostasis via
tailored urinary excretion. Kidney injuries that cause severe or progressive chronic kidney …

Physiology assays in human kidney organoids

BS Freedman - American Journal of Physiology-Renal …, 2022 - journals.physiology.org
Kidney organoids derived from human pluripotent stem cells constitute a novel model of
disease, development, and regenerative therapy. Organoids are human, experimentally …

Navigating the kidney organoid: insights into assessment and enhancement of nephron function

N Tabibzadeh, LM Satlin, S Jain… - American Journal of …, 2023 - journals.physiology.org
Kidney organoids are three-dimensional structures generated from pluripotent stem cells
(PSCs) that are capable of recapitulating the major structures of mammalian kidneys. As this …

[HTML][HTML] Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells

H Tsujimoto, A Hoshina, SI Mae, T Araoka… - Cell Reports, 2024 - cell.com
Recent regenerative studies using human pluripotent stem cells (hPSCs) have developed
multiple kidney-lineage cells and organoids. However, to further form functional segments of …

Kidney organoid research: current status and applications

O Trush, M Takasato - Current Opinion in Genetics & Development, 2022 - Elsevier
Organoids are being widely introduced as novel research models in multiple research fields.
Human-induced pluripotent stem cells-derived kidney organoids became an indispensable …