Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Scientists and health professionals are exhaustively trying to contain the coronavirus
disease 2019 (COVID-19) pandemic by elucidating viral invasion mechanisms, possible …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

P2X receptors are trimeric, non-selective cation channels activated by extracellular ATP. The
P2X 7 receptor subtype is a pharmacological target because of involvement in apoptotic …

P2X receptors are trimeric ATP-activated ion channels permeable to Na+, K+ and Ca2+. The
seven P2X receptor subtypes are implicated in physiological processes that include …

Recognition of sweet, bitter and umami tastes requires the non-vesicular release from taste
bud cells of ATP, which acts as a neurotransmitter to activate afferent neural gustatory …

P2X receptors are trimeric, non-selective cation channels activated by ATP that have
important roles in the cardiovascular, neuronal and immune systems. Despite their central …

The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 5′-
triphosphate. The receptor is present on an increasing number of different cells types …

Extracellular nucleotides have been recognized as important mediators of activation,
triggering multiple responses via plasma membrane receptors known as P2 receptors. P2 …

New Findings• What is the topic of this review? This is a personal historical review about the
discovery and the main conceptual advances leading to our current understanding of …