Coumarins as modulators of the Keap1/Nrf2/ARE signaling pathway
EHM Hassanein, AM Sayed… - Oxidative Medicine …, 2020 - Wiley Online Library
The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress
which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a …
which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a …
[HTML][HTML] Radical oxygen species: an important breakthrough point for botanical drugs to regulate oxidative stress and treat the disorder of glycolipid metabolism
M Luo, Y Zheng, S Tang, L Gu, Y Zhu, R Ying… - Frontiers in …, 2023 - frontiersin.org
Background: The incidence of glycolipid metabolic diseases is extremely high worldwide,
which greatly hinders people's life expectancy and patients' quality of life. Oxidative stress …
which greatly hinders people's life expectancy and patients' quality of life. Oxidative stress …
lncRNA GAS5/miR-452-5p reduces oxidative stress and pyroptosis of high-glucose-stimulated renal tubular cells
C Xie, W Wu, A Tang, N Luo, Y Tan - Diabetes, metabolic syndrome …, 2019 - Taylor & Francis
Background Diabetic nephropathy (DN) is the leading cause of end-stage renal failure
worldwide. lncRNAs are demonstrated to improve the DN by changing the expression of …
worldwide. lncRNAs are demonstrated to improve the DN by changing the expression of …
Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention
X Ma, J Ma, T Leng, Z Yuan, T Hu, Q Liu, T Shen - Renal failure, 2023 - Taylor & Francis
Diabetic kidney disease (DKD) is a common complication of diabetes and has become the
leading cause of end-stage kidney disease. The pathogenesis of DKD is complicated, and …
leading cause of end-stage kidney disease. The pathogenesis of DKD is complicated, and …
Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy
E Wang, L Wang, R Ding, M Zhai, R Ge, P Zhou… - Pharmacological …, 2020 - Elsevier
Diabetic nephropathy (DN), a common complication of diabetes mellitus, is the main cause
of end-stage nephropathy, and thus developing novel strategies for reversing DN remains …
of end-stage nephropathy, and thus developing novel strategies for reversing DN remains …
Total coumarin derivates from Hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement …
W Wang, L Sheng, Y Chen, Z Li, H Wu, J Ma, D Zhang… - Phytomedicine, 2022 - Elsevier
Background Total coumarins extracted from Hydrangea. Paniculata, Sieb (HP) have showed
renal protective effect in several experimental acute and chronic kidney diseases. Purpose …
renal protective effect in several experimental acute and chronic kidney diseases. Purpose …
Altered intestinal microbial flora and metabolism in patients with idiopathic membranous nephropathy
X Shi, Z Li, W Lin, W Shi, R Hu, G Chen, X Li… - American Journal of …, 2023 - karger.com
Introduction: Dysbiosis of the intestinal microbiome and related metabolites have been
observed in chronic kidney disease, yet their roles in idiopathic membranous nephropathy …
observed in chronic kidney disease, yet their roles in idiopathic membranous nephropathy …
A review of coumarins and coumarin-related compounds for their potential antidiabetic effect
S Ranđelović, R Bipat - Clinical Medicine Insights …, 2021 - journals.sagepub.com
Background and aims: Worldwide, type 2 diabetes mellitus accounts for a considerable
burden of disease, with an estimated global cost of> 800 billion USD annually. For this …
burden of disease, with an estimated global cost of> 800 billion USD annually. For this …
Aesculetin exhibited anti-inflammatory activities through inhibiting NF-кB and MAPKs pathway in vitro and in vivo
SK Wang, TX Chen, W Wang, LL Xu, YQ Zhang… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Aesculetin (6, 7-dihydroxy-2H-1-benzopyran-2-
one) has been reported to exhibit potent anti-inflammatory property both in vitro and in vivo …
one) has been reported to exhibit potent anti-inflammatory property both in vitro and in vivo …
7-hydroxycoumarin-β-D-glucuronide protects against cisplatin-induced acute kidney injury via inhibiting p38 MAPK-mediated apoptosis in mice
H Wu, X Shi, Y Zang, X Zhao, X Liu, W Wang, W Shi… - Life Sciences, 2023 - Elsevier
Aims Cisplatin is a widely-used drug in the clinical treatment of tumors, but kidney
nephrotoxicity is one of the reasons that limits its widespread use. We previously found that …
nephrotoxicity is one of the reasons that limits its widespread use. We previously found that …