The secretion of glucocorticoids (GCs) is a classic endocrine response to stress. Despite
that, it remains controversial as to what purpose GCs serve at such times. One view …

NF-κB in defense and disease ing lymphocyte activation (8). The chemotherapeutic agent
etoposide also increases NF-κB levels and thereby induces A1/Bfl-1, which prevents …

Apart from genetic and environmental factors, the mucosal immune system of the gut plays a
central role in the pathogenesis of inflammatory bowel disease (IBD). In the healthy gut, the …

A reciprocal regulation exists between the central nervous and immune systems through
which the CNS signals the immune system via hormonal and neuronal pathways and the …

We show that a combination of the immunosuppressive drugs, vitamin D3 and
Dexamethasone, induced human and mouse naive CD4+ T cells to differentiate in vitro into …

The inflammatory response is a highly regulated physiological process that is critically
important for homeostasis. A precise physiological control of inflammation allows a timely …

Interleukin-6 (IL-6) is a pleiotropic cytokine, whose plasma levels are elevated in
inflammatory diseases such as atherosclerosis. We have previously reported that …

The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the
regulation of expression of numerous genes in the setting of the inflammatory response …

Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune
response and have been used since decades to treat various inflammatory and autoimmune …

Glucocorticoids are small lipophilic compounds that mediate their many biological effects by
binding an intracellular receptor (GR) that, in turn, translocates to the nucleus and directly or …