2-substituted benzothiazoles as antiproliferative agents: Novel insights on structure-activity relationships
Given the wide spectrum of biological activities, benzothiazoles represent privileged
scaffolds in medicinal chemistry, useful in drug discovery programs to modulate biological …
scaffolds in medicinal chemistry, useful in drug discovery programs to modulate biological …
Recent advances in Bcr‐Abl tyrosine kinase inhibitors for overriding T315I mutation
J Liu, Y Zhang, H Huang, X Lei, G Tang… - Chemical Biology & …, 2021 - Wiley Online Library
BCR‐ABL is a gene produced by the fusion of the bcr gene and the c‐abl proto‐oncogene
and is considered to be the main cause of chronic myelogenous leukemia (CML) production …
and is considered to be the main cause of chronic myelogenous leukemia (CML) production …
New horizons in benzothiazole scaffold for cancer therapy: Advances in bioactivity, functionality, and chemistry
In the pasture of oncology, anticancer agents having advanced modes of action are of great
interest because of increasing chronicity of resistance against anticancer drugs. Heterocyclic …
interest because of increasing chronicity of resistance against anticancer drugs. Heterocyclic …
The significance of N-methylpicolinamides in the development of anticancer therapeutics: Synthesis and structure-activity relationship (SAR) studies
Cancer is the second most important cause of death worldwide. There is always a demand
for new anticancer drugs and continuously a wide variety of natural and synthetic …
for new anticancer drugs and continuously a wide variety of natural and synthetic …
Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase …
AK El-Damasy, JH Lee, SH Seo, NC Cho… - European Journal of …, 2016 - Elsevier
A new series of benzothiazole amide and urea derivatives tethered with the privileged
pyridylamide moiety by ether linkage at the 6-position of benzothiazole (22 final compounds) …
pyridylamide moiety by ether linkage at the 6-position of benzothiazole (22 final compounds) …
Benzothiazoles: From recent advances in green synthesis to anti-cancer potential
Abstract According to World Health Organization Cancer is the second leading cause of
death worldwide which accounted for an estimated 10.0 million deaths in 2020. Globally, the …
death worldwide which accounted for an estimated 10.0 million deaths in 2020. Globally, the …
Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma
Glioblastoma is the most common and aggressive form of primary brain cancer, with median
survival of 16–20 months and a 5‐year survival rates of< 5%. Recent advances in …
survival of 16–20 months and a 5‐year survival rates of< 5%. Recent advances in …
Novel small molecule inhibitors targeting renal cell carcinoma: Status, challenges, future directions
L Xiong, Y Zhang, J Wang, M Yu, L Huang… - European Journal of …, 2024 - Elsevier
Renal cell carcinoma (RCC) is the most common renal malignancy with a rapidly increasing
morbidity and mortality rate gradually. RCC has a high mortality rate and an extremely poor …
morbidity and mortality rate gradually. RCC has a high mortality rate and an extremely poor …
Design, synthesis, in-vitro antiproliferative activity and kinase profile of new picolinamide based 2-amido and ureido quinoline derivatives
AK El-Damasy, SH Seo, NC Cho, SB Kang… - European Journal of …, 2015 - Elsevier
New 2-amido and ureido quinoline derivatives substituted with 2-N-methylamido-pyridin-4-
yloxy group at the 5-position of quinoline (18 final compounds) have been designed and …
yloxy group at the 5-position of quinoline (18 final compounds) have been designed and …
[HTML][HTML] Design and synthesis of new 4-(3, 4, 5-trimethoxyphenyl) thiazole–pyrimidine derivatives as potential antiproliferative agents
A new series of 3, 4, 5-trimethoxyphenyl thiazole pyrimidines has been synthesized and
biologically evaluated for its in vitro anticancer activity. Compounds 4a, 4b, and 4h with …
biologically evaluated for its in vitro anticancer activity. Compounds 4a, 4b, and 4h with …