Several recent studies have emphasized a crucial role for the interactions between
serotonergic and dopaminergic systems in movement control and the pathophysiology of …

Serotonin receptors (5-HTRs) are implicated in the pathophysiology of a variety of
neuropsychiatric and neurodegenerative disorders and are also targets for drug therapy. In …

The tremendous advances in transgene animal technology, especially in the area of
Alzheimer's disease, have not resulted in a significantly better success rate for drugs …

Mapping of the human brain is more than the generation of an atlas-based parcellation of
brain regions using histologic or histochemical criteria. It is the attempt to provide a …

Of the many serotonin receptors, the type 3 receptors (5-HT3R) are the only ionotropic ones,
playing a key role in fast synaptic transmission and cognitive and emotional brain function …

Compelling data demonstrate that inflammation-associated anorexia directly results from the
action of pro-inflammatory factors, primarily cytokines and prostaglandins E2, on the nervous …

Abstract 5HT 3 receptors (5HT3Rs) have long been identified as a potential target for
antidepressants. Several studies have reported that antagonism of 5HT3Rs produces …

Background: Vortioxetine (VRX) is a multimodal antidepressant that acts as serotonin (5HT)
transporter inhibitor as well as 5HT3A and 5HT7 receptors antagonist, 5HT1A and 5HT1B …

Gilles de la Tourette syndrome (GTS)(MIM 137580) is a complex neuropsychiatric disorder
probably originating from a disturbed interplay of several neurotransmitter systems in the …

BACKGROUND: Irritable bowel syndrome (IBS) is the most common functional bowel
disorder and has a strong predominance in women. Recent data suggest that the brain may …