Nausea and vomiting are ubiquitous as drug side effects and symptoms of disease;
however, the systems that determine these responses are arguably designed for protection …

The pentameric 5-HT3 receptor complex is a ligand-gated ion channel that mediates fast
synaptic transmission in the brain. Expression of two subunits (5-HT3A and 5-HT3B …

Adrenoceptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Page 1
IUPHAR/BPS Guide to Pharmacology CITE https://doi.org/10.2218/gtopdb/F4/2019.4 …

Successful disease modifying drug development for Alzheimer's disease (AD) has hit a
roadblock with the recent failures of amyloid-based therapies, highlighting the translational …

Our objective was to develop an array of α7-selective nicotinic cholinergic receptor (nAChR)–
based imaging agents for PET and SPECT. Methods:(2′ R)-N-11C-Methyl-N …

Non‐Technical Summary The serotonin 3 receptor is a ligand‐gated ion channel which is
activated by the neurotransmitter serotonin. This receptor is present in many parts of the …

The incidence of postoperative nausea and vomiting (PONV) can be as high as 80% in
patients with risk factors (eg, females, history of motion sickness). PONV delays …

An important group of antiemetic drugs used in the treatment of nausea and vomiting after
chemotherapy containing an indole moiety in their structures, working as 5 …

Abstract Serotonin (5‐HT) plays an important role in the pathophysiology of irritable bowel
syndrome (IBS). Using α‐[11C] methyl‐l‐tryptophan‐positron emission tomography (PET), it …

Serotonin 5-HT 3 receptors are involved in various brain functions including as an emesis
target during cancer chemotherapy. We report here the development of (S)-2, 3-dimethoxy-5 …