Mathematical models of HIV pathogenesis and treatment
We review mathematical models of HIV dynamics, disease progression, and therapy. We
start by introducing a basic model of virus infection and demonstrate how it was used to …
start by introducing a basic model of virus infection and demonstrate how it was used to …
The HIV coreceptor switch: a population dynamical perspective
RR Regoes, S Bonhoeffer - Trends in microbiology, 2005 - cell.com
Over the course of infection, the coreceptor usage of the HIV virus changes from a
preference for CCR5 to a preference for CXCR4 in∼ 50% of infected individuals. The …
preference for CCR5 to a preference for CXCR4 in∼ 50% of infected individuals. The …
HIV–1 dynamics revisited: biphasic decay by cytotoxic T lymphocyte killing?
RA Arnaout, N Martin A… - Proceedings of the …, 2000 - royalsocietypublishing.org
The biphasic decay of blood viraemia in patients being treated for human immunodeficiency
virus type 1 (HIV–1) infection has been explained as the decay of two distinct populations of …
virus type 1 (HIV–1) infection has been explained as the decay of two distinct populations of …
Compartmentalization of the gut viral reservoir in HIV-1 infected patients
G van Marle, MJ Gill, D Kolodka, L McManus, T Grant… - Retrovirology, 2007 - Springer
Background Recently there has been an increasing interest and appreciation for the gut as
both a viral reservoir as well as an important host-pathogen interface in human …
both a viral reservoir as well as an important host-pathogen interface in human …
[PDF][PDF] HIV-1 fitness: implications for drug resistance, disease progression, and global epidemic evolution
ME Quiñones-Mateu, EJ Arts - HIV sequence compendium, 2001 - mit.edu
In the past five years, the HIV research field has shown renewed interest in the replicative
capacity of human immunodeficiency virus type 1 (HIV-1) due to the potential impact of ex …
capacity of human immunodeficiency virus type 1 (HIV-1) due to the potential impact of ex …
Virus fitness: concept, quantification, and application to HIV population dynamics
ME Quinones-Mateu, EJ Arts - Quasispecies: Concept and Implications for …, 2006 - Springer
Viral fitness has been broadly studied during the past three decades, mainly to test
evolutionary models and population theories difficult to analyze and interpret with more …
evolutionary models and population theories difficult to analyze and interpret with more …
Dynamics of macrophage and T cell infection by HIV
We analyse mathematical models comparing thein vivodynamics of macrophage-and T cell
infection by HIV. Experiments suggest that HIV can only replicate in activated T cells …
infection by HIV. Experiments suggest that HIV can only replicate in activated T cells …
A new theory of cytotoxic T–lymphocyte memory: implications for HIV treatment
We use simple mathematical models to examine the dynamics of primary and secondary
cytotoxic T–lymphocyte (CTL) responses to viral infections. In particular, we are interested in …
cytotoxic T–lymphocyte (CTL) responses to viral infections. In particular, we are interested in …
Immune responses and viral phenotype: do replication rate and cytopathogenicity influence virus load?
We use mathematical models to investigate the relationship between viral characteristics
and virus load under the following immune responses:(a) CTL‐mediated lysis,(b) CTL …
and virus load under the following immune responses:(a) CTL‐mediated lysis,(b) CTL …
[HTML][HTML] Persistence and emergence of X4 virus in HIV infection
AD Weinberger, AS Perelson - Mathematical biosciences and …, 2011 - ncbi.nlm.nih.gov
Approximately 50% of late-stage HIV patients develop CXCR4-tropic (X4) virus in addition to
CCR5-tropic (R5) virus. X4 emergence occurs with a sharp decline in CD4+ T cell counts …
CCR5-tropic (R5) virus. X4 emergence occurs with a sharp decline in CD4+ T cell counts …