Hydrogenase enzymes efficiently process H2 and protons at organometallic FeFe, NiFe, or
Fe active sites. Synthetic modeling of the many H2ase states has provided insight into …

The reaction takes place at a specialized metal center that dramatically increases the acidity
of H2 and leads to a heterolytic splitting of the molecule which is strongly accelerated by the …

It was once widely held that nearly all reactions in biology were catalyzed via mechanisms
involving paired electron species. Beginning approximately 40 years ago, this paradigm was …

Reduction of oxides and oxoanions of carbon and nitrogen are of great contemporary
importance as they are crucial for a sustainable environment. Substantial research has been …

Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron
donor in all organisms. It provides the reducing power that drives numerous anabolic …

Natural photosynthesis uses sunlight to drive the conversion of energy-poor molecules
(H2O, CO2) to energy-rich ones (O2,(CH2O) n). Scientists are working hard to develop …

High levels of anthropogenic CO 2 emissions are driving the warming of global climate. If
this pattern of increasing emissions does not change, it will cause further climate change …

This article sets out to review the chemistry relating to the synthesis of structural and
functional analogues of the three classes of hydrogenases. This chemistry has grown …

If the atmosphere of the early Earth was hydrogen-rich, 1 it is reasonable to think that
hydrogenases, the enzymes enabling cells to use molecular hydrogen, were probably …

Ever since the discovery of hydrogenases over 90 years ago (Stephenson and Stickland,
1931), their structure and mechanism of action have been intensively investigated. Of the …