Selective removal of the basal forebrain cholinergic neurons by the immunotoxin 192
immunoglobulin G-saporin has offered a new powerful tool for the study of the relationships …

Extensive research suggests that long-term potentiation (LTP) may serve as a cellular
mechanism for memory and that alterations in synaptic plasticity may underlie the gross …

Cholinergic systems were linked to cognitive processes like attention and memory. Other
neurotransmitter systems having minor influence on cognitive functions–as shown by the …

The basal forebrain comprises several heterogeneous neuronal subgroupings having
modular projection patterns to discrete sets of cortical subregions. Each cortical region forms …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive
decline and neurodegeneration in the hippocampus. Despite the pathological importance of …

Basal forebrain cholinergic neurons play an important role in cognitive functions such as
learning and memory, and they are affected in several neurodegenerative diseases …

Use of the selective immunotoxin; 192 IgG-saporin, is helping to elucidate the role of the
cholinergic system in cognition by overcoming the problems of interpretation associated with …

In a previous experiment [Eur J Neurosci 12 (2000) 79], combined intracerebroventricular
injections of 5, 7-dihydroxytryptamine (5, 7-DHT; 150 μg) and 192 IgG-saporin (2 μg) in …

Overexpression or aberrant processing of the β-amyloid precursor protein (APP) and loss of
cortical cholinergic function represent two hallmark pathological features of Alzheimer's …

Background Cholinergic neuronal dysfunction of the basal forebrain is observed in patients
with Alzheimer's disease and dementia, and has been linked to decreased neurogenesis in …