Problem statement: Demand for cognitive-enhancing drugs is growing. Numerous medicinal
plants possessing antioxidant activity have received much attention as food supplement to …

Three-month-old Long–Evans rats were subjected to intraseptal infusions of 0.8 μg of 192
IgG–saporin followed, 2 weeks later, by intrahippocampal suspension grafts containing fetal …

Adults rats were lesioned with 192-IgG-saporin, an immunotoxin that targets cholinergic
neurons in the basal forebrain expressing the low-affinity nerve growth factor receptor (p75) …

The current challenge of studying the mechanisms involving memory formation requires the
possibility of capacity to analyze in the different brain regions that comprise the neuronal …

Immunotoxins provide the opportunity to make neurotoxic lesions of specific
neurochemically-defined neuronal populations (see Chapter 17) by targeting cell-surface …

The cyto-and chemoarchitecture of basal forebrain cholinergic neurons (BFCN) was
investigated in the lower primate, the common marmoset (Callithrix jacchus). A large …

The neural cell adhesion molecule (NCAM) is implicated in nervous system development
and plasticity. In humans, abnormal NCAM expression has been linked to the pathogenesis …

A key component of the cognitive deficits associated with aging is the loss of function of
cholinergic neurons in the basal forebrain due to neuronal losses and decreased …

The aim of this study was to examine the effects of histaminergic antagonists on memory
upon injection into the region of the nucleus basalis magnocellularis (NBM). In experiment 1 …

The use of targeted toxins in research applications has recently grown considerably. The
ability to remove a few specific cells, even when surrounded by different populations, has …