Inheritance of epigenetic transcriptional memory

T Ge, JH Brickner - Current Opinion in Genetics & Development, 2024 - Elsevier
Highlights•Epigenetic transcriptional regulation allows for maintenance of stable expression
states.•Epigenetic regulation requires DNA methylation, lncRNAs or histone modifications.• …

X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes

H Topa, C Benoit-Pilven, T Tukiainen, O Pietiläinen - Genome Biology, 2024 - Springer
Background Variation in X chromosome inactivation (XCI) in human-induced pluripotent
stem cells (hiPSCs) can impact their ability to model biological sex biases. The gene-wise …

Nanosheet coating improves stability of human pluripotent stem cell culture on glass substrates

Y Sakata, H Zhang, A Sugiyama, N Motosugi… - Biochemical and …, 2023 - Elsevier
High-resolution imaging analysis using various types of cells is an essential tool for
dissecting cell functions. Generally, obtaining such images requires the cells to be cultured …

Effect of PCDH19 missense mutation on cell-to-cell proximity and neuronal development under heterotypic condition

N Motosugi, A Sugiyama, A Otomo, Y Sakata… - PNAS …, 2024 - academic.oup.com
The mutation of X-linked protocadherin (PCDH) 19 gene in heterozygous females causes
epilepsy. However, because of the erosion of X-chromosome inactivation (XCI) in female …

Sex-biased gene expression during neural differentiation of human embryonic stem cells

P Pottmeier, D Nikolantonaki, F Lanner… - Frontiers in Cell and …, 2024 - frontiersin.org
Sex differences in the developing human brain are primarily attributed to hormonal
influence. Recently however, genetic differences and their impact on the developing …

X-chromosome inactivation in human iPSCs provides insight into escape-regulated gene expression.

H Topa, C Benoit-Pilven, T Tukiainen, O Pietilainen - bioRxiv, 2023 - biorxiv.org
Epigenetic variation in the X chromosome inactivation (XCI) of human induced pluripotent
stem cells (hiPSCs) can impact their ability to accurately model biological sex biases …

Erosion of X-Chromosome Inactivation in female hiPSCs is heterogeneous and persists during differentiation

AC Raposo, P Caldas, M Arez, J Jeremias, P Barbosa… - bioRxiv, 2024 - biorxiv.org
During culture, female human pluripotent stem cells (hPSCs), including human induced
PSCs (hiPSCs) exhibit a propensity for erosion of X-chromosome inactivation (XCI). This …

Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity

N Krivec, E Couvreu de Deckersberg, Y Lei… - bioRxiv, 2023 - biorxiv.org
Gains of 1q are a highly recurrent chromosomal abnormality in human pluripotent stem cells.
In this work, we show that gains of 1q impact the differentiation capacity to derivates of the …

Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity

C Spits, N Krivec, EC de Deckersberg, Y Lei… - 2023 - researchsquare.com
Gains of 1q are a highly recurrent chromosomal abnormality in human pluripotent stem cells.
In this work, we show that gains of 1q impact the differentiation capacity to derivates of the …