Background Hyperuricemia refers to a metabolic disorder associated with high serum uric
acid levels and is regarded as a major risk factor not only for the development of gout but …

Globally, inflammation and metabolic disorders pose serious public health problems and are
major health concerns. It has been shown that natural polyphenols are effective in the …

Molecular docking and activity evaluation screened the dipeptide module GP with low
xanthine oxidase (XOD) inhibitory activity and modules KE and KN with high activity, and …

Background α-Viniferin, the major constituent of the roots of Caragana sinica (Buc'hoz)
Rehder with a trimeric resveratrol oligostilbenoid skeleton, was demonstrated to possess a …

Ethnopharmacological relevance Excessive serum uric acid (SUA) causes hyperuricemic
nephropathy (HN), characterized by inflammatory infiltration and tubulointerstitial fibrosis …

Hesperetin is a natural flavonoid with many biological activities. In view of hyperuricemia
treatment, the effects of hesperetin in vivo and in vitro, and the underlying mechanisms, were …

Ethnopharmacological relevance: The genus Alternanthera (Amaranthaceae) comprises
139 species including 14 species used traditionally for the treatment of various ailments …

Objective. Hyperuricemia (HUA) is a common metabolic disease caused by disordered
purine metabolism. We aim to reveal the mechanisms underlying the anti‐HUA function of …

Hyperuricemia is a metabolic disease caused by the accumulation of uric acid in the body.
Allopurinol, benzbromarone, and febuxostat, which are available in the market, have …

Hyperuricemic nephropathy (HN) is caused by urate crystals that get deposited in the kidney
and contribute to renal fibrosis. Uric acid (UA) has been proven to directly cause renal …