Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells

F Casiraghi, N Azzollini, P Cassis, B Imberti… - The Journal of …, 2008 - journals.aai.org
In this study, we investigated whether mesenchymal stem cells (MSC) had
immunomodulatory properties in solid organ allotransplantation, using a semiallogeneic …

[HTML][HTML] Treatment of autoimmune diseases by hematopoietic stem cell transplantation

S Ikehara - Experimental hematology, 2001 - Elsevier
Remarkable advances have been made in bone marrow transplantation (BMT), which now
has become a powerful strategy for the treatment of leukemia, aplastic anemia, congenital …

Intra–bone marrow injection of allogeneic bone marrow cells: a powerful new strategy for treatment of intractable autoimmune diseases in MRL/lpr mice

T Kushida, M Inaba, H Hisha, N Ichioka… - Blood, The Journal …, 2001 - ashpublications.org
Intractable autoimmune diseases in chimeric resistant MRL/lpr mice were treated by a new
bone marrow transplantation (BMT) method consisting of fractionated irradiation, 5.5 Gy× 2 …

Bone marrow transplantation: a new strategy for intractable diseases.

S Ikehara - Drugs of Today (Barcelona, Spain: 1998), 2002 - europepmc.org
Bone marrow transplantation is becoming a powerful strategy for the treatment of
hematologic disorders (leukemia, aplastic anemia, etc.), congenital immunodeficiencies …

Treatment of streptozotocin-induced diabetes mellitus by transplantation of islet cells plus bone marrow cells via portal vein in rats1

K Ikebukuro, Y Adachi, Y Yamada, S Fujimoto… - …, 2002 - journals.lww.com
Background. We have established a new method for the transplantation of allogeneic
pancreatic islets (PIs) using sublethal irradiation (9 Gy) plus simultaneous transplantation of …

Immunity or tolerance: opposite outcomes of microchimerism from skin grafts

CC Anderson, P Matzinger - Nature medicine, 2001 - nature.com
Solid organ transplants contain small numbers of leukocytes that can migrate into the host
and establish long-lasting microchimerism. Although such microchimerism is often …

Crucial role of donor-derived stromal cells in successful treatment for intractable autoimmune diseases in MRL/lpr mice by BMT via portal vein

T Kushida, M Inaba, H Hisha, N Ichioka, T Esumi… - Stem …, 2001 - academic.oup.com
We have recently established a new bone marrow transplantation (BMT) method for the
treatment of intractable autoimmune diseases in MRL/lpr mice; the method consists of …

Successful multilineage engraftment of human cord blood cells in pigs after in utero transplantation

Y Fujiki, K Fukawa, K Kameyama, O Kudo… - …, 2003 - journals.lww.com
Background. Successful engraftment of human hematopoietic stem and progenitor cells
(HSPCs) in a large animal may serve not only as a model to study human hematopoiesis but …

Treatment of intractable autoimmune diseases in MRL/lpr mice using a new strategy for allogeneic bone marrow transplantation

T Kushida, M Inaba, K Takeuchi… - Blood, The Journal …, 2000 - ashpublications.org
A new bone marrow transplantation (BMT) method for treating severe autoimmune diseases
in chimeric resistant MRL/lpr mice is presented. The method consists of fractionated …

Administration of an antigen at a high dose generates regulatory CD4+ T cells expressing CD95 ligand and secreting IL-4 in the liver

T Watanabe, M Yoshida, Y Shirai, M Yamori… - The Journal of …, 2002 - journals.aai.org
Ags administered orally at a high dose are absorbed in immunogenic forms and perfuse the
liver, which raises a question regarding the relevance of hepatic lymphocyte activation to the …